Leucine supplementation does not attenuate the decline in daily muscle protein synthesis rates or preserve leg muscle mass during leg immobilization in young or older adults: a double-blind randomized trial.
- 2026-04
- RCT
- The American journal of clinical nutrition 123(4)
- Tyler A Churchward-Venne
- Philippe Jm Pinckaers
- Joey Sj Smeets
- Gabriel Nasri Marzuca-Nassr
- Stefan Hm Gorissen
- Cas J Fuchs
- Joan M Senden
- Joy Pb Goessens
- Annemie P Gijsen
- Will Kwh Wodzig
- Luc Jc van Loon
- PubMed: 41580240
- DOI: 10.1016/j.ajcnut.2026.101205
- High evidence
- Mixed
CSA decreased by ∼1.2% and ∼1.1% in the IM leg … with no differences between LEU compared with PLA (treatment: P = 0.374 and P = 0.998).
- Effect
- Neutral
- Effect size
- Small
- Significant
- No
- Dose
- 5 g 3 × daily with each main meal