L-Methylfolate and Improved Depressive Symptoms

• A Review of l-Methylfolate as Adjunctive Therapy in the Treatment of Major Depressive Disorder.

  • 2023-05-09
  • Review
  • The primary care companion for CNS disorders 25(3)
  • • Vladimir Maletic
    • Richard Shelton
    • Valerie Holmes

  • PubMed: 37192264
  • DOI: 10.4088/pcc.22nr03361

  2 Insights on

  • Improved Depressive Symptoms

  • Low evidence
  • Clinical

  These studies support the use of LMF as an adjunctive treatment in patients with MDD not responding to antidepressant monotherapy. The most effective dose tested was 15 mg/day.

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

  Dose

  15 mg/day