Best Supplements for Improved Depressive Symptoms
Ranked by research evidence. Compare 24 supplements across 32 papers from the biomedical literature, with effect direction, evidence strength, and dose range for each.
Top picks by evidence
- Low evidence4 studies
Across 4 studies, all reported beneficial effects of Bifidobacterium bifidum Rosell-71 on depressive symptoms, with effect sizes ranging from small to moderate. The highest-quality evidence (a systematic review of 3,353 adults with psychiatric disorders) found a moderate beneficial effect. Evidence is predominantly from reviews and systematic reviews; no individual RCT data was extracted.
- Low evidence3 studies
Across 3 review-level studies, all reported beneficial effects of Bifidobacterium breve Rosell-70 on depressive symptoms, with effect sizes ranging from small to moderate. Two of the three studies reported statistically significant findings. The evidence base is limited to reviews, with no extracted data on dose, form, or study duration, so specific dosing or population guidance cannot be determined.
- LowBifidobacterium bifidum Rosell-71Across 4 studies, all reported beneficial effects of Bifidobacterium bifidum Rosell-71 on depressive symptoms, with effect sizes ranging from small to moderate. The highest-quality evidence (a systematic review of 3,353 adults with psychiatric disorders) found a moderate beneficial effect. Evidence is predominantly from reviews and systematic reviews; no individual RCT data was extracted.4 beneficial4 studies
- LowBifidobacterium breve Rosell-70Across 3 review-level studies, all reported beneficial effects of Bifidobacterium breve Rosell-70 on depressive symptoms, with effect sizes ranging from small to moderate. Two of the three studies reported statistically significant findings. The evidence base is limited to reviews, with no extracted data on dose, form, or study duration, so specific dosing or population guidance cannot be determined.3 beneficial3 studies