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Evidence-Based Supplement Research
Evidence-Based Supplement Research

Best Supplements for Improved Depressive Symptoms

Ranked by research evidence. Compare 20 supplements across 27 papers from the biomedical literature, with effect direction, evidence strength, and dose range for each.

Top picks by evidence

  • Low evidence4 studies

    Across 4 studies, all reported beneficial effects of Bifidobacterium bifidum Rosell-71 on depressive symptoms, with effect sizes ranging from small to moderate. Evidence is drawn primarily from systematic reviews and reviews, including one large systematic review (n=3,353) showing moderate benefits; no specific dose or form data were consistently reported across studies.

  • Low evidence3 studies

    Across 3 studies (all reviews), all reported beneficial effects on depressive symptoms, with effect sizes ranging from small to moderate (predominantly moderate). The evidence is based on reviews of psychobiotics/probiotics, not exclusively on Bifidobacterium breve Rosell-70. The small number of studies limits certainty.

20 supplements
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