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St. John's Wort

Safety profile

6 studies reporting safety data2 serious adverse events

Across 6 clinical studies, no specific adverse events were quantitatively reported for St. John's Wort. The supplement was described as generally well tolerated in 4 of these studies, with some mentioning fewer side effects compared to conventional antidepressants. However, two studies flagged serious concerns: one highlighted the risk of serotonin syndrome when combined with other serotonergic agents, and another noted the potential for drug interactions, particularly with CYP 450 substrates, which requires careful consideration of the safety profile.

Caveats: Evidence is limited to a small number of studies, many of which were not primarily designed for safety assessment. The serious adverse event findings (serotonin syndrome, drug interactions) are based on qualitative mentions rather than controlled comparisons, and the overall safety in long-term use or specific populations (e.g., pregnant women, children) remains uncharacterized.

Most-studied combinations with St. John's Wort

most supplement research is combination research
Also studied with:Valerian (2), Passion Flower (2), Lavender (3), Ginkgo (2), Saffron (3)

  • St. John's Wort Herb

    By Nature's Way

    4.5 (3.9K reviews)
    Out of Stock
    Available From
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    Amazon
    $-
    		Out
    iHerb
    $14.31
    		In
    Vitacost
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    Vitamin Shoppe
    $-
    		Out

  • Bye-Lori Plus

    By Life Enhancement

    4.3 (299 reviews)
    Out of Stock
    Available From
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    Amazon
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    		Out
    iHerb
    $72.70
    		In
    Vitacost
    $-
    		Out
    Vitamin Shoppe
    $-
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  • St. John's Wort

    By Solaray

    4.5 (247 reviews)
    Out of Stock
    Available From
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    Amazon
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    		Out
    iHerb
    $17.49
    		In
    Vitacost
    $-
    		Out
    Vitamin Shoppe
    $-
    		Out

  • St. John's Wort 450

    By Source Naturals

    4.5 (244 reviews)
    In Stock
    Available From
    Available From
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    Amazon
    $-
    		Out
    iHerb
    $22.79
    		In
    Vitacost
    $-
    		Out
    Vitamin Shoppe
    $-
    		Out

  • St. John's Wort

    By NOW Foods

    4.5 (1.4K reviews)
    Out of Stock
    Available From
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    Amazon
    $-
    		Out
    iHerb
    $20.81
    		In
    Vitacost
    $-
    		Out
    Vitamin Shoppe
    $-
    		Out

  • St. John's Wort Extract

    By Lake Avenue Nutrition

    4.6 (3.2K reviews)
    In Stock
    Available From
    Available From
    MerchantPriceStockAction
    Amazon
    $-
    		Out
    iHerb
    $19.06
    		In
    Vitacost
    $-
    		Out
    Vitamin Shoppe
    $-
    		Out
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