Skip to main content
Evidence-Based Supplement Research
Evidence-Based Supplement Research
Pillser
Search
Sign UpLog In

St. John's Wort

Safety profile

4 studies reporting safety data2 serious adverse events

Across 4 clinical studies, no specific adverse events were reported as significantly increased compared to control. St. John's Wort was described as generally well tolerated in multiple studies, with some reports noting fewer side effects than conventional antidepressants. However, serious safety concerns were flagged in two studies, including a predisposition to serotonin syndrome when combined with other serotonergic agents and the need for caution due to potential drug interactions with CYP 450 substrates.

Caveats: Evidence is limited to a small number of studies; absence of reported adverse events does not establish safety. Most findings are qualitative and unquantified, and studies were likely not powered to detect rare or serious adverse events. Drug interaction risks are highlighted but not systematically quantified across all studies.

Most-studied combinations with St. John's Wort

most supplement research is combination research
Also studied with:Passion Flower (2), Lavender (2), Ginkgo (2), Saffron (2)

  • St. John's Wort Herb

    By Nature's Way

    4.5 (3.9K reviews)
    Out of Stock
    Available From
    Available From
    MerchantPriceStockAction
    Amazon
    $-
    		Out
    iHerb
    $14.31
    		In
    Vitacost
    $-
    		Out
    Vitamin Shoppe
    $-
    		Out

  • Bye-Lori Plus

    By Life Enhancement

    4.3 (299 reviews)
    Out of Stock
    Available From
    Available From
    MerchantPriceStockAction
    Amazon
    $-
    		Out
    iHerb
    $72.70
    		In
    Vitacost
    $-
    		Out
    Vitamin Shoppe
    $-
    		Out

  • St. John's Wort

    By Solaray

    4.5 (247 reviews)
    Out of Stock
    Available From
    Available From
    MerchantPriceStockAction
    Amazon
    $-
    		Out
    iHerb
    $17.49
    		In
    Vitacost
    $-
    		Out
    Vitamin Shoppe
    $-
    		Out

  • St. John's Wort 450

    By Source Naturals

    4.5 (244 reviews)
    In Stock
    Available From
    Available From
    MerchantPriceStockAction
    Amazon
    $-
    		Out
    iHerb
    $22.79
    		In
    Vitacost
    $-
    		Out
    Vitamin Shoppe
    $-
    		Out

  • St. John's Wort

    By NOW Foods

    4.5 (1.4K reviews)
    Out of Stock
    Available From
    Available From
    MerchantPriceStockAction
    Amazon
    $-
    		Out
    iHerb
    $20.81
    		In
    Vitacost
    $-
    		Out
    Vitamin Shoppe
    $-
    		Out

  • St. John's Wort Extract

    By Lake Avenue Nutrition

    4.6 (3.2K reviews)
    In Stock
    Available From
    Available From
    MerchantPriceStockAction
    Amazon
    $-
    		Out
    iHerb
    $19.06
    		In
    Vitacost
    $-
    		Out
    Vitamin Shoppe
    $-
    		Out
Back to top