St. John's Wort and Improved Depressive Symptoms

Safety in these studies

Overall tolerabilityReported
SJW is better tolerated with fewer adverse effects when compared to standardized antidepressants
from: Advantages and Disadvantages of Using St. John's Wort as a Treatment for Depression.
drug interactionsReported
drug interactions noted with CYP 450 drugs, raises a question in the safety profile
from: Advantages and Disadvantages of Using St. John's Wort as a Treatment for Depression.
serotonin syndromeReportedSerious adverse event
its predisposition to causing fatal serotonin syndrome, when used in conjunction with other serotonergic agents
from: Advantages and Disadvantages of Using St. John's Wort as a Treatment for Depression.

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Advantages and Disadvantages of Using St. John's Wort as a Treatment for Depression.