Bifidobacterium breve Rosell-70 and Improved Depressive Symptoms

Research synthesisLow evidenceModerate effect3 studies · 3 beneficial · 0 neutral · 0 harmful

Across 3 studies, all reported beneficial effects on depressive symptoms, with predominantly moderate effect sizes. Two of the three studies reported statistically significant findings. The evidence is based on broad reviews of psychobiotics and probiotics, not on direct trials of Bifidobacterium breve Rosell-70 specifically.

Caveats: The three studies are broad reviews of psychobiotics and probiotics for depression; they do not isolate the effects of Bifidobacterium breve Rosell-70 specifically. Direct evidence for this strain is lacking, and effect sizes reflect general probiotic interventions. No dose, form, or duration data were reported.

Generated May 11, 2026

3 of 3 papers

Psychobiotics in Depression: Sources, Metabolites, and Treatment-A Systematic Review.
- 2025-06-27
- Systematic Review
- Nutrients 17(13)
- - Angelika Śliwka
  - Magdalena Polak-Berecka
  - Kinga Zdybel
  - Agnieszka Zelek-Molik
  - Adam Waśko
- PubMed: 40647242
- DOI: 10.3390/nu17132139
1 Insight on
- Improved Depressive Symptoms
- High evidence
- Rigorous Journal
Lactobacillus plantarum ... demonstrated particularly promising effects ... Psychobiotics show significant potential as adjunctive and therapeutic agents in depressive disorders through modulation of the gut-brain axis.
Effect
Beneficial
Effect size
Moderate
Rewiring Mood: Precision Psychobiotics as Adjunct or Stand-Alone Therapy in Depression Using Insights from 19 Randomized Controlled Trials in Adults.
- 2025-06-17
- Review
- Nutrients 17(12)
- - Alexandra-Eleftheria Menni
  - Helen Theodorou
  - Georgios Tzikos
  - Ioannis M Theodorou
  - Eleni Semertzidou
  - Veroniki Stelmach
  - Anne D Shrewsbury
  - George Stavrou
  - Katerina Kotzampassi
- PubMed: 40573133
- DOI: 10.3390/nu17122022
4 Insights on
- Improved Depressive Symptoms
- Moderate evidence
- Rigorous Journal
all demonstrating a significant amelioration of depression status after probiotic/psychobiotic treatment... In total, 7 out of 10 studies with probiotics as an add-on therapy ... exhibited a significant amelioration of depression status against placebo treatment.
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Probiotics as Modulators of Adult Neurogenesis and Synaptic Plasticity: New Perspectives in the Pathophysiology and Treatment of Affective Disorders.
- 2026-03-12
- Review
- Biomedicines 14(3)
- - Gilberto Uriel Rosas-Sánchez
  - León Jesús Germán-Ponciano
  - María Isabel Pérez-Vega
  - Oscar Gutiérrez-Coronado
  - José Luis Muñoz-Carrillo
  - Alejandro David Soriano-Hernández
  - Abril Alondra Barrientos-Bonilla
  - Carmen Gabriela Rosales-Muñoz
  - Cesar Soria-Fregozo
- PubMed: 41898284
- DOI: 10.3390/biomedicines14030637
4 Insights on
- Improved Depressive Symptoms
- Low evidence
clinical evidence from randomized controlled trials and recent meta-analyses indicates that probiotic supplementation produces significant reductions in depressive and anxiety symptoms
Effect
Beneficial
Effect size
Small
Significant
Yes

Bifidobacterium breve Rosell-70 and Improved Depressive Symptoms

Psychobiotics in Depression: Sources, Metabolites, and Treatment-A Systematic Review.

Rewiring Mood: Precision Psychobiotics as Adjunct or Stand-Alone Therapy in Depression Using Insights from 19 Randomized Controlled Trials in Adults.

Probiotics as Modulators of Adult Neurogenesis and Synaptic Plasticity: New Perspectives in the Pathophysiology and Treatment of Affective Disorders.