Bifidobacterium breve Rosell-70 and Improved Depressive Symptoms

Research synthesisLow evidenceModerate effect3 studies · 3 beneficial · 0 neutral · 0 harmful

Across 3 studies (all reviews), all reported beneficial moderate-sized effects on depressive symptoms, with two reaching statistical significance. The evidence base is small and consists largely of reviews, so conclusions should be considered preliminary.

Studied populations: adults

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed).

Generated Jul 12, 2026

3 of 3 papers

Psychobiotics in Depression: Sources, Metabolites, and Treatment-A Systematic Review.
- 2025-06-27
- Systematic Review
- Nutrients 17(13)
- - Angelika Śliwka
  - Magdalena Polak-Berecka
  - Kinga Zdybel
  - Agnieszka Zelek-Molik
  - Adam Waśko
- PubMed: 40647242
- DOI: 10.3390/nu17132139
1 Insight on
- Improved Depressive Symptoms
- High evidence
- Rigorous Journal
Lactobacillus plantarum ... demonstrated particularly promising effects ... Psychobiotics show significant potential as adjunctive and therapeutic agents in depressive disorders through modulation of the gut-brain axis.
Effect
Beneficial
Effect size
Moderate
Rewiring Mood: Precision Psychobiotics as Adjunct or Stand-Alone Therapy in Depression Using Insights from 19 Randomized Controlled Trials in Adults.
- 2025-06-17
- Review
- Nutrients 17(12)
- - Alexandra-Eleftheria Menni
  - Helen Theodorou
  - Georgios Tzikos
  - Ioannis M Theodorou
  - Eleni Semertzidou
  - Veroniki Stelmach
  - Anne D Shrewsbury
  - George Stavrou
  - Katerina Kotzampassi
- PubMed: 40573133
- DOI: 10.3390/nu17122022
4 Insights on
- Improved Depressive Symptoms
- Moderate evidence
- Rigorous Journal
all demonstrating a significant amelioration of depression status after probiotic/psychobiotic treatment... In total, 7 out of 10 studies with probiotics as an add-on therapy ... exhibited a significant amelioration of depression status against placebo treatment.
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Probiotics as Modulators of Adult Neurogenesis and Synaptic Plasticity: New Perspectives in the Pathophysiology and Treatment of Affective Disorders.
- 2026-03-12
- Review
- Biomedicines 14(3)
- - Gilberto Uriel Rosas-Sánchez
  - León Jesús Germán-Ponciano
  - María Isabel Pérez-Vega
  - Oscar Gutiérrez-Coronado
  - José Luis Muñoz-Carrillo
  - Alejandro David Soriano-Hernández
  - Abril Alondra Barrientos-Bonilla
  - Carmen Gabriela Rosales-Muñoz
  - Cesar Soria-Fregozo
- PubMed: 41898284
- DOI: 10.3390/biomedicines14030637
4 Insights on
- Improved Depressive Symptoms
- Low evidence
clinical evidence from randomized controlled trials and recent meta-analyses indicates that probiotic supplementation produces significant reductions in depressive and anxiety symptoms
Effect
Beneficial
Effect size
Small
Significant
Yes

Bifidobacterium breve Rosell-70 and Improved Depressive Symptoms

Psychobiotics in Depression: Sources, Metabolites, and Treatment-A Systematic Review.

Rewiring Mood: Precision Psychobiotics as Adjunct or Stand-Alone Therapy in Depression Using Insights from 19 Randomized Controlled Trials in Adults.

Probiotics as Modulators of Adult Neurogenesis and Synaptic Plasticity: New Perspectives in the Pathophysiology and Treatment of Affective Disorders.