Bifidobacterium bifidum Rosell-71 and Improved Depressive Symptoms

• Effectiveness of Psychobiotics in the Treatment of Psychiatric and Cognitive Disorders: A Systematic Review of Randomized Clinical Trials.

  • 2024-04-30
  • Systematic Review · n = 3,353
  • Nutrients 16(9)
  • • Freiser Eceomo Cruz Mosquera
    • Santiago Lizcano Martinez
    • Yamil Liscano

  • PubMed: 38732599
  • DOI: 10.3390/nu16091352

  1 Insight on

  • Improved Depressive Symptoms

  • High evidence
  • Rigorous Journal

  There was a notably high measurement of effectiveness specifically in the treatment of depression symptoms.

  • Beneficial
  • Moderate effect

• Psychobiotics in Depression: Sources, Metabolites, and Treatment-A Systematic Review.

  • 2025-06-27
  • Systematic Review
  • Nutrients 17(13)
  • • Angelika Śliwka
    • Magdalena Polak-Berecka
    • Kinga Zdybel
    • Agnieszka Zelek-Molik
    • Adam Waśko

  • PubMed: 40647242
  • DOI: 10.3390/nu17132139

  1 Insight on

  • Improved Depressive Symptoms

  • High evidence
  • Rigorous Journal

  Lactobacillus plantarum ... demonstrated particularly promising effects ... Psychobiotics show significant potential as adjunctive and therapeutic agents in depressive disorders through modulation of the gut-brain axis.

  • Beneficial
  • Moderate effect

• Rewiring Mood: Precision Psychobiotics as Adjunct or Stand-Alone Therapy in Depression Using Insights from 19 Randomized Controlled Trials in Adults.

  • 2025-06-17
  • Review
  • Nutrients 17(12)
  • • Alexandra-Eleftheria Menni
    • Helen Theodorou
    • Georgios Tzikos
    • Ioannis M Theodorou
    • Eleni Semertzidou
    • Veroniki Stelmach
    • Anne D Shrewsbury
    • George Stavrou
    • Katerina Kotzampassi

  • PubMed: 40573133
  • DOI: 10.3390/nu17122022

  4 Insights on

  • Improved Depressive Symptoms

  • Moderate evidence
  • Rigorous Journal

  all demonstrating a significant amelioration of depression status after probiotic/psychobiotic treatment... In total, 7 out of 10 studies with probiotics as an add-on therapy ... exhibited a significant amelioration of depression status against placebo treatment.

  • Beneficial
  • Moderate effect
  • Significant

• Host-microbiome relationship in depression: can human induced pluripotent stem cells play a role in unravelling mechanisms?

  • 2025-07-01
  • Review
  • NPJ biofilms and microbiomes 11(1)
  • • Cristina Rosell-Cardona
    • John F Cryan
    • Gerard Clarke
    • Sarah Kittel-Schneider

  • PubMed: 40595695
  • DOI: 10.1038/s41522-025-00749-z

  2 Insights on

  • Improved Depressive Symptoms

  • Low evidence

  This review explores the emerging field of hiPSCs and their potential in advancing microbiota-gut-brain axis science and depression research.

  • Beneficial
  • Small effect