Host-microbiome relationship in depression: can human induced pluripotent stem cells play a role in unravelling mechanisms?
- 2025-07-01
- NPJ biofilms and microbiomes 11(1)
- PubMed: 40595695
- DOI: 10.1038/s41522-025-00749-z
Study Design
- Type
- Review
- Methods
- This review explores the emerging field of hiPSCs and their potential in advancing microbiota-gut-brain axis science and depression research.
Depression is highly prevalent, with many patients not responding to existing treatments. The gut microbiota plays a key role in its pathophysiology, offering new therapeutic avenues. Human-based research is essential to uncover mechanisms and validate new targets. Given CNS inaccessibility, human induced pluripotent stem cells (hiPSCs) offer an innovative model. This review explores the emerging field of hiPSCs and their potential in advancing microbiota-gut-brain axis science and depression research.
Research Insights
| Supplement | Dose | Health Outcome | Effect Type | Effect Size | Source |
|---|---|---|---|---|---|
| Bifidobacterium bifidum Rosell-71 | — | Improved Depressive Symptoms | Beneficial | Small | View sourceThis review explores the emerging field of hiPSCs and their potential in advancing microbiota-gut-brain axis science and depression research. |
| Lactobacillus helveticus Rosell-52 | — | Reduced Depression Symptoms | Beneficial | Small | View sourceconsuming Lactobacillus helveticus Rosell-52... has been associated with improvements in mood and stress-related outcomes in some studies, suggesting a potential role in depression research |