Lactobacillus helveticus Rosell-52 and Reduced Depression Symptoms

• Role of Probiotics in Management of Depressive Symptoms and Cognitive Impairment in Patients With Depression: An Updated Analysis of Trials.

  • 2025-11-29
  • Meta-Analysis
  • Brain and behavior 15(12)
  • • Syed Ali Arsal
    • Aashish Kumar
    • Umer Iqbal
    • Shafin Bin Amin
    • Muhammad Aniq Amir
    • Muhammad Abrar Amir
    • Muhammad Ashir Shafique
    • Suhaib Ahmed
    • Laksh Kumar
    • Oluwatobiloba Israel Popoola
    • Inibehe Ime Okon

  • PubMed: 41319022
  • DOI: 10.1002/brb3.71108

  2 Insights on

  • Reduced Depression Symptoms

  • High evidence

  the probiotic group had a significant reduction in depressive symptoms compared to the placebo group (p = 0.03; SMD, -0.55; 95% CI, -1.04 to -0.06; I2 = 79%)

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

• Rewiring Mood: Precision Psychobiotics as Adjunct or Stand-Alone Therapy in Depression Using Insights from 19 Randomized Controlled Trials in Adults.

  • 2025-06-17
  • Review
  • Nutrients 17(12)
  • • Alexandra-Eleftheria Menni
    • Helen Theodorou
    • Georgios Tzikos
    • Ioannis M Theodorou
    • Eleni Semertzidou
    • Veroniki Stelmach
    • Anne D Shrewsbury
    • George Stavrou
    • Katerina Kotzampassi

  • PubMed: 40573133
  • DOI: 10.3390/nu17122022

  4 Insights on

  • Reduced Depression Symptoms

  • Moderate evidence
  • Rigorous Journal

  Nineteen RCTs met the inclusion criteria, with all demonstrating a significant amelioration of depression status after probiotic/psychobiotic treatment... Probiotics, particularly multi-strain preparations and certain well-characterized single strains, seem to be noticeably beneficial in alleviating depressive symptoms in adults.

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

• Probiotics for Anxiety and Depressive Symptoms in Cancer: A Systematic Review of Animal and Human Studies with Mechanistic Insights.

  • 2025-12-25
  • Review
  • Microorganisms 14(1)
  • • Zahra Amirkhanzadeh Barandouzi
    • Deborah Watkins Bruner
    • Yufen Lin
    • Hannah Choi
    • Layla R Zeki
    • Tobi Akangbe
    • Amruta Epari
    • Hongjin Li

  • PubMed: 41597571
  • DOI: 10.3390/microorganisms14010051

  6 Insights on

  • Reduced Depression Symptoms

  • Low evidence

  Some trials reported improvements in anxiety, and depressive symptoms, while others showed no significant differences compared with control groups.

  Effect

  Beneficial

  Effect size

  Small

• Host-microbiome relationship in depression: can human induced pluripotent stem cells play a role in unravelling mechanisms?

  • 2025-07-01
  • Review
  • NPJ biofilms and microbiomes 11(1)
  • • Cristina Rosell-Cardona
    • John F Cryan
    • Gerard Clarke
    • Sarah Kittel-Schneider

  • PubMed: 40595695
  • DOI: 10.1038/s41522-025-00749-z

  2 Insights on

  • Reduced Depression Symptoms

  • Low evidence

  consuming Lactobacillus helveticus Rosell-52... has been associated with improvements in mood and stress-related outcomes in some studies, suggesting a potential role in depression research

  Effect

  Beneficial

  Effect size

  Small