L-Methylfolate and Reduced Depression Symptoms

• Systematic Review and Meta-Analysis of L-Methylfolate Augmentation in Depressive Disorders.

  • 2021-11-18
  • Meta-Analysis · n = 707
  • Pharmacopsychiatry 55(03)
  • • Abdullah Al Maruf
    • Ethan A Poweleit
    • Lisa C Brown
    • Jeffrey R Strawn
    • Chad A Bousman

  • PubMed: 34794190
  • DOI: 10.1055/a-1681-2047

  2 Insights on

  • Reduced Depression Symptoms

  • High evidence
  • Clinical

  A meta-analysis of four studies (N=507) using a continuous measure of depressive symptoms showed a similar effect of adjunctive L-methylfolate (standardized mean difference=-0.38, 95% CI=-0.59 to -0.17, p=0.0003)

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes