L-Methylfolate and Reduced Homocysteine Level

• l-5-Methyltetrahydrofolate Supplementation Increases Blood Folate Concentrations to a Greater Extent than Folic Acid Supplementation in Malaysian Women.

  • 2018-06
  • RCT · n = 142
  • The Journal of nutrition 148(6)
  • • Amanda M Henderson
    • Rika E Aleliunas
    • Su Peng Loh
    • Geok Lin Khor
    • Sarah Harvey-Leeson
    • Melissa B Glier
    • David D Kitts
    • Tim J Green
    • Angela M Devlin

  • PubMed: 29878267
  • DOI: 10.1093/jn/nxy057

  15 Insights on

  • Reduced Homocysteine Level

  • High evidence
  • Large Human Trial
  • Adults

  The folic acid and l-5-MTHF groups had 17% and 15%, respectively, lower (P < 0.001) plasma total homocysteine concentrations than did the placebo group at 12 wk; there were no differences between the folic acid and l-5-MTHF groups.

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

  Dose

  1 mg (2.27 μmol)/day

• 5-MTHF enhances the portal pressure reduction achieved with propranolol in patients with cirrhosis: A randomized placebo-controlled trial.

  • 2023-10
  • RCT
  • Journal of hepatology 79(4)
  • • Ranka Vukotic
    • Roberto Di Donato
    • Greta Roncarati
    • Patrizia Simoni
    • Matteo Renzulli
    • Stefano Gitto
    • Filippo Schepis
    • Erica Villa
    • Annalisa Berzigotti
    • Jaume Bosch
    • Pietro Andreone

  • PubMed: 37482222
  • DOI: 10.1016/j.jhep.2023.06.017

  5 Insights on

  • Reduced Homocysteine Level

  • High evidence
  • Clinical

  lower tHcy (μmol/L, 11.0 ± 4.6 vs. 15.4 ± 7.2 μmol/L, p=0.010)

  Effect

  Beneficial

  Effect size

  Small

  Significant

  Yes