Best Supplements for Reduced Homocysteine Level
Ranked by research evidence. Compare 10 supplements across 18 papers from the biomedical literature, with effect direction, evidence strength, and dose range for each.
Top picks by evidence
- High evidence7 studies
Across 7 studies, 6 reported beneficial effects of Vitamin B9 supplementation on reducing homocysteine levels, with a predominant effect size ranging from small to moderate. Most evidence comes from randomized controlled trials and meta-analyses in clinical populations (e.g., coronary heart disease, type 2 diabetes) and healthy adults, with doses typically around 1 mg/day and effects observed at 8–12 weeks. The median study duration was 84 days, indicating sustained supplementation is typical for achieving reductions.
Dose: 1 mg/day
10 supplements
- HighVitamin B9Across 7 studies, 6 reported beneficial effects of Vitamin B9 supplementation on reducing homocysteine levels, with a predominant effect size ranging from small to moderate. Most evidence comes from randomized controlled trials and meta-analyses in clinical populations (e.g., coronary heart disease, type 2 diabetes) and healthy adults, with doses typically around 1 mg/day and effects observed at 8–12 weeks. The median study duration was 84 days, indicating sustained supplementation is typical for achieving reductions. · Dose: 1 mg/day6 beneficial1 neutral7 studies