L-Selenomethionine and Reduced Thyroid Peroxidase Antibody Level

• Selenium supplementation in the management of thyroid autoimmunity during pregnancy: results of the "SERENA study", a randomized, double-blind, placebo-controlled trial.

  • 2019-05-25
  • RCT
  • Endocrine 66(3)
  • • G Mantovani
    • A M Isidori
    • C Moretti
    • C Di Dato
    • E Greco
    • P Ciolli
    • M Bonomi
    • L Petrone
    • A Fumarola
    • G Campagna
    • G Vannucchi
    • S Di Sante
    • C Pozza
    • A Faggiano
    • A Lenzi
    • E Giannetta

  • PubMed: 31129812
  • DOI: 10.1007/s12020-019-01958-1

  11 Insights on

  • Reduced Thyroid Peroxidase Antibody Level

  • High evidence
  • Clinical

  We measured a significant reduction of autoantibodies after pregnancy in L-Se-Met group [at PP: TgAb 19.86 (11.59-52.60), p < 0.01; TPOAb 255.00 (79.00-292.00), p < 0.01]

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

  Dose

  83 mcg/day

• Effects of 12 months treatment with L-selenomethionine on serum anti-TPO Levels in Patients with Hashimoto's thyroiditis.

  • 2007-07
  • Clinical Trial · n = 80
  • Thyroid : official journal of the American Thyroid Association 17(7)
  • • Elias E Mazokopakis
    • John A Papadakis
    • Maria G Papadomanolaki
    • Antony G Batistakis
    • Triantafillos G Giannakopoulos
    • Eftichios E Protopapadakis
    • Emmanuel S Ganotakis

  • PubMed: 17696828
  • DOI: 10.1089/thy.2007.0040

  2 Insights on

  • Reduced Thyroid Peroxidase Antibody Level

  • High evidence
  • Clinical

  There was a significant reduction of serum anti-TPO levels during the first 6 months (by 5.6% and 9.9% at 3 and 6 months, respectively). An overall reduction of 21% (p < 0.0001) compared with the basal values was noted in Group A.

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

  Dose

  200 microg Se in the form of l-selenomethionine orally for 6 months