Best Supplements for Reduced Thyroid Peroxidase Antibody Level
Ranked by research evidence. Compare 5 supplements across 10 papers from the biomedical literature, with effect direction, evidence strength, and dose range for each.
Top picks by evidence
- High evidence5 studies
Across 5 studies on selenium for reducing thyroid peroxidase antibody (TPOAb) levels, 4 reported beneficial effects and 1 was neutral. The two highest-quality meta-analyses both found moderate-to-large statistically significant reductions in TPOAb among patients with Hashimoto thyroiditis (e.g., SMD -0.80 at 6 months in one 2025 meta-analysis of 1,610 patients). Effects were typically observed at 3–6 months (median study duration 182 days), supporting sustained supplementation for antibody reduction.
5 supplements
- HighSeleniumAcross 5 studies on selenium for reducing thyroid peroxidase antibody (TPOAb) levels, 4 reported beneficial effects and 1 was neutral. The two highest-quality meta-analyses both found moderate-to-large statistically significant reductions in TPOAb among patients with Hashimoto thyroiditis (e.g., SMD -0.80 at 6 months in one 2025 meta-analysis of 1,610 patients). Effects were typically observed at 3–6 months (median study duration 182 days), supporting sustained supplementation for antibody reduction.4 beneficial1 neutral5 studies