Best Supplements for Reduced Thyroid Peroxidase Antibody Level
Ranked by research evidence. Compare 3 supplements across 7 papers from the biomedical literature, with effect direction, evidence strength, and dose range for each.
Top picks by evidence
- High evidence5 studies
Across 5 studies, 4 reported beneficial effects of selenium supplementation on reducing thyroid peroxidase antibody (TPOAb) levels, with effect sizes ranging from small to large. Two large meta-analyses (2024 and 2025) demonstrated statistically significant moderate-to-large reductions (SMD -0.46 to -0.96). Effects were typically observed in clinical populations with Hashimoto thyroiditis or Graves-Basedow disease, over durations of 3–6 months (median study duration 182 days).
3 supplements
- HighSeleniumAcross 5 studies, 4 reported beneficial effects of selenium supplementation on reducing thyroid peroxidase antibody (TPOAb) levels, with effect sizes ranging from small to large. Two large meta-analyses (2024 and 2025) demonstrated statistically significant moderate-to-large reductions (SMD -0.46 to -0.96). Effects were typically observed in clinical populations with Hashimoto thyroiditis or Graves-Basedow disease, over durations of 3–6 months (median study duration 182 days).4 beneficial1 neutral5 studies