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Evidence-Based Supplement Research
Evidence-Based Supplement Research
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Selenium and Reduced Thyroid Peroxidase Antibody Level

Research synthesisModerate evidenceModerate effect4 studies · 4 beneficial · 0 neutral · 0 harmful

Across 4 studies, all reported beneficial effects of selenium supplementation on reducing thyroid peroxidase antibody (TPOAb) levels, with effect sizes ranging from small to large. The two highest-quality meta-analyses (total N ≈ 4,000) showed moderate-to-large reductions (SMD -0.46 to -0.96) in patients with Hashimoto thyroiditis. Effects were observed at 3–6 months; dose and form were not consistently reported.

  • Studied populations: patients with Hashimoto thyroiditis; patients with Graves-Basedow disease orbitopathy

Caveats: Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Evidence base is small (only 4 studies) — conclusions should be considered preliminary. Dose and form were not extracted, limiting specificity for consumer guidance. Most evidence comes from meta-analyses with high heterogeneity (I²=90% in the largest study).

Generated May 12, 2026
Safety in these studies
4 of 4 papers
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