Research synthesisLow evidenceMixed effect size3 studies · 1 beneficial · 2 neutral · 0 harmful
Across 3 studies, 1 reported a beneficial large effect on reducing IL-6 levels, while 2 found neutral effects. The only significant finding came from a meta-analysis showing a large reduction, but two RCTs in clinical populations (older adults with vitamin D deficiency, rheumatoid arthritis patients) using 600–1200 mg/day for a median of 70 days found no significant effect. The evidence is mixed, with a single beneficial study conflicting with two neutral trials.
- Effective dose range: 600–1200 mg/day
- Studied populations: clinical populations including older adults with vitamin D deficiency and rheumatoid arthritis patients
Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Many of the included studies did not reach statistical significance — effect may be smaller than the predominant direction suggests. The single beneficial finding comes from a meta-analysis, while two small RCTs showed no significant effect, indicating inconsistency.
Generated Jul 14, 2026