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Evidence-Based Supplement Research

Evidence-Based Supplement Research

N-Acetyl Cysteine and Reduced Interleukin-6 Levels

Doses used in studies

mg/day: 600 (median 600, IQR 600–600) — 1 study

Time to effect

Median: 8 weeks · IQR 8 weeks–8 weeks · Range 8 weeks–8 weeks — Reported in 1 of 2 studies

2 of 2 papersPopulation:

The impact of N-acetylcysteine on lactate, biomarkers of oxidative stress, immune response, and muscle damage: A systematic review and meta-analysis.
- 2024-12
- Meta-Analysis · n = 20
- Journal of cellular and molecular medicine 28(23)
- - Marcin Sadowski
  - Emilia Zawieja
  - Agata Chmurzynska
- PubMed: 39632267
- DOI: 10.1111/jcmm.70198
8 Insights on
- Reduced Interleukin-6 Levels
- High evidence
A substantial decrease was observed in concentrations of IL-6 (p=0.03; the standardized MD (SMD) was -1.71; 95% CI, -3.26, -0.16)
Effect
Beneficial
Effect size
Large
Significant
Yes
Co-administration of vitamin D and N-acetylcysteine to modulate immunosenescence in older adults with vitamin D deficiency: a randomized clinical trial.
- 2025-05-12
- RCT
- Frontiers in immunology 16
- - Samira Rastgoo
  - Katayoun Pourvali
  - Seyed Ahmad Raeissadat
  - Ghazaleh Eslamian
  - Hamid Zand
- PubMed: 40421021
- DOI: 10.3389/fimmu.2025.1570441
6 Insights on
- Reduced Interleukin-6 Levels
- High evidence
- Clinical
No significant differences were observed between the groups in serum IL-6 ... after the intervention.
Effect
Neutral
Effect size
Small
Significant
No
Dose
1000 IU daily