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Evidence-Based Supplement Research

Evidence-Based Supplement Research

N-Acetyl Cysteine and Reduced Oxidative Stress

Doses used in studies

mg/day: 600–1,200 (median 900, IQR 600–1,200) — 1 study

Time to effect

Median: 3.7 months · IQR 3.7 months–3.7 months · Range 3.7 months–3.7 months — Reported in 1 of 2 studies

2 of 2 papers

Effect of N-acetyl cysteine in children with metabolic dysfunction-associated steatotic liver disease-A pilot study.
- 2024-07-08
- RCT · n = 13
- Journal of pediatric gastroenterology and nutrition 79(3)
- - P Babu Balagopal
  - Rohit Kohli
  - Vikas Uppal
  - Lauren Averill
  - Chetan Shah
  - Katherine McGoogan
  - Matthew Di Guglielmo
  - Michael Goran
  - Md Jobayer Hossain
- PubMed: 38973318
- DOI: 10.1002/jpn3.12312
4 Insights on
- Reduced Oxidative Stress
- High evidence
- Clinical
Sixteen-week NAC treatment improved ... oxidative stress (GSH)
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Dose
either 600 or 1200 mg NAC/day
Effects of antioxidants on oxidative stress in adult patients with coronary artery disease: A systematic review.
- 2025-10
- Systematic Review
- Clinical nutrition ESPEN 69
- - Islam M Alhusban
  - Misook L Chung
  - Martha Biddle
- PubMed: 40914496
- DOI: 10.1016/j.clnesp.2025.08.037
1 Insight on
- Reduced Oxidative Stress
- High evidence
- Clinical
nine reported on supplemental antioxidants (i.e., L-carnitine and melatonin) ... that were effective at lowering OS (P < 0.05)
Effect
Beneficial
Effect size
Moderate
Significant
Yes