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Evidence-Based Supplement Research
Evidence-Based Supplement Research
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N-Acetyl Cysteine and Reduced Oxidative Stress

Research synthesisLow evidenceModerate effect3 studies · 3 beneficial · 0 neutral · 0 harmful

Across 3 studies, 3 reported beneficial effects of N-Acetyl Cysteine (NAC) on reducing oxidative stress, with moderate effect sizes in the highest-quality study. The best evidence comes from a 16-week pilot RCT in children with metabolic dysfunction-associated steatotic liver disease (MASLD) using 600–1200 mg/day NAC, showing moderate effects on oxidative stress markers like GSH. Effects were typically observed at 112 days (16 weeks), and the evidence base is small.

  • Effective dose range: 600-1200 mg/day
  • Studied populations: children with MASLD and obesity, adults with coronary artery disease

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). One study had a very low evidence score (review), limiting overall certainty.

Generated Jun 12, 2026
Doses used in studies
  • mg/day: 600–1,200 (median 900, IQR 600–1,200) — 1 study
Time to effect
Median: 3.7 months · IQR 3.7 months–3.7 months · Range 3.7 months–3.7 months — Reported in 1 of 3 studies
Safety in these studies
3 of 3 papers
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