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Evidence-Based Supplement Research
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N-Acetyl Cysteine and Reduced Oxidative Stress

Research synthesisLow evidenceModerate effect3 studies · 3 beneficial · 0 neutral · 0 harmful

Across 3 studies, all 3 reported beneficial effects of N-Acetyl Cysteine (NAC) on reducing oxidative stress, with moderate effect sizes in 2 studies and a small effect in 1. The most-studied doses were 600–1200 mg/day, and effects were observed in clinical populations including children with obesity/MASLD and adults with coronary artery disease. Median study duration was 112 days (16 weeks), though only 1 of 3 studies reported duration.

  • Effective dose range: 600–1200 mg/day
  • Studied populations: children with metabolic dysfunction-associated steatotic liver disease (MASLD) and obesity; adult patients with coronary artery disease

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Two of the three studies are reviews, and the only RCT had a very small sample size (n=13).

Generated Jul 12, 2026
Doses used in studies
  • mg/day: 600–1,200 (median 900, IQR 600–1,200) — 1 study
Time to effect
Median: 3.7 months · IQR 3.7 months–3.7 months · Range 3.7 months–3.7 months — Reported in 1 of 3 studies
Safety in these studies
3 of 3 papers
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