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Evidence-Based Supplement Research
Evidence-Based Supplement Research
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Myth-buster

In a triple-blind trial, a single 200 mg dose of bromelain led to more chewing pain at 48 hours than ibuprofen — though it matched ibuprofen for pain intensity earlier.

This finding complicates the common belief that bromelain is a straightforward pain reliever, but the result is narrow — limited to chewing pain at one time point in a single small study, so the picture is far from settled.

Among 135 people receiving orthodontic separators, those who took a single 200 mg dose of bromelain reported higher pain scores specifically when chewing at the 48-hour mark compared to the ibuprofen group. At other times and for overall pain intensity, bromelain performed similarly to ibuprofen, meaning the harmful effect was limited to a specific function and time point.

Where this fits in the evidence

This is among the first studies we've indexed on Bromelain for Reduced Chewing Pain — treat it as an early signal until more research accumulates.

The study

Analgesic Efficacy of Bromelain and Bromelain Plus Turmeric for Pain Control After Orthodontic Separator Placement: A Triple-Blind Randomized Clinical Trial.

  • Randomized Controlled Trial (RCT)
  • n = 135
  • 2025-04-01
  • Clinical and experimental dental research
More on BromelainMore on Reduced Chewing Pain

This is a plain-language summary of a research finding, not medical advice. Pillser surfaces research signals to help you decide what's worth investigating — always consult a qualified professional before changing what you take.

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