New evidence
A 16-week trial found Cissus quadrangularis boosted the fullness hormone GLP-1 by 42.2 pg/mL – the first solid evidence for this herb, pending replication.
This large, double-blind RCT provides the first rigorous evidence that Cissus quadrangularis extract can raise GLP-1 levels in overweight adults, a promising signal for weight management — but because it's a single early study, caution is warranted until independent teams confirm the results.
The study gave 300 mg/day of Cissus quadrangularis extract to 248 overweight adults for 16 weeks. Those taking the extract saw their GLP-1 levels rise by an average of 42.2 pg/mL compared to placebo. GLP-1 is a hormone that signals fullness and helps regulate blood sugar. The researchers also observed significant weight and fat loss. However, this is the first large trial on this supplement, so the findings should be considered preliminary until they are reproduced.
Where this fits in the evidence
This is among the first studies we've indexed on Cissus quadrangularis for Increased Intestinal GLP-1 Levels — treat it as an early signal until more research accumulates.
The study
- Randomized Controlled Trial (RCT)
- n = 248
- 2025-12-25
- Medicina (Kaunas, Lithuania)
This is a plain-language summary of a research finding, not medical advice. Pillser surfaces research signals to help you decide what's worth investigating — always consult a qualified professional before changing what you take.