Big effect
A systematic review linked L-citrulline to systolic blood pressure drops of up to 9 mmHg in some studies — but only in hypertensive postmenopausal women, and other vascular and metabolic measures showed no consistent benefit.
This is one of the first reviews to focus on L-citrulline specifically in this population, so the finding is novel but narrow: the blood pressure effect is promising, yet the same review found no significant improvements in arterial stiffness, muscle strength, or metabolic markers, meaning the benefit may be limited to one outcome in a specific group.
The review pooled evidence from multiple studies and found that L-citrulline supplementation reduced systolic blood pressure by up to 9 mmHg in some trials involving postmenopausal women with high blood pressure. However, other key measures like artery flexibility, muscle strength, and blood sugar control showed no significant change, so the effect appears focused on blood pressure rather than a broad health boost. The dose used wasn't specified in the abstract, and since this is among the first indexed reviews on the topic, the results should be treated as preliminary rather than definitive.
Where this fits in the evidence
This is among the first studies we've indexed on L-Citrulline for Reduced Systolic Blood Pressure — treat it as an early signal until more research accumulates.
The study
- Systematic Review
- 2026-01-26
- BMC women's health
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