Big effect
Lactobacillus acidophilus L-92 tied to unusually large drops in CRP and TNF-α — but other inflammation markers stayed unchanged
This meta-analysis links a specific probiotic to substantial reductions in two key inflammation markers, but since several related measures didn't budge and the evidence is still early, the overall anti-inflammatory role remains uncertain.
CRP and TNF-α are two important markers of systemic inflammation. In this analysis of randomized trials, Lactobacillus acidophilus L-92 was associated with large decreases in these markers (CRP down by a standardized mean difference of -1.33, TNF-α down by -1.10). However, other markers like IL-6, nitric oxide, and total antioxidant capacity were not significantly affected, suggesting the effect may be limited to specific inflammatory pathways. This is among the first meta-analyses on this pairing, so the findings are intriguing but far from conclusive.
Where this fits in the evidence
This is among the first studies we've indexed on Lactobacillus acidophilus L-92 for Reduced Inflammation Markers — treat it as an early signal until more research accumulates.
The study
- Meta-Analysis
- 2025-07-01
- BMC pharmacology & toxicology
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