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Evidence-Based Supplement Research
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Surprising

Probiotic LA85 prevented antibiotic diarrhea in under-53s — but the overall trial was negative

This is one of the first studies on this specific strain-antibiotic pairing, so the subgroup finding is exploratory and needs replication before drawing firm conclusions.

In 82 adults taking amoxicillin, Lactobacillus acidophilus LA85 did not significantly reduce overall diarrhea rates. However, in those under 53, it sharply cut diarrhea incidence (p=0.008). Other measures like stool consistency and diarrhea duration didn't improve, and serious adverse events occurred, though the probiotic was generally well tolerated.

Where this fits in the evidence

This is among the first studies we've indexed on Lactobacillus acidophilus LA85 for Reduced Diarrhea Rate — treat it as an early signal until more research accumulates.

The study

Efficacy and Safety of Lactobacillus acidophilus LA85 in Preventing Antibiotic-Associated Diarrhea: A Randomized, Placebo-Controlled Study.

  • Randomized Controlled Trial (RCT)
  • n = 82
  • 2025-06
  • Food science & nutrition
More on Lactobacillus acidophilus LA85More on Reduced Diarrhea Rate

This is a plain-language summary of a research finding, not medical advice. Pillser surfaces research signals to help you decide what's worth investigating — always consult a qualified professional before changing what you take.

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