Efficacy and Safety of Lactobacillus acidophilus LA85 in Preventing Antibiotic-Associated Diarrhea: A Randomized, Placebo-Controlled Study.
- 2025-06
- RCT · n = 82
- Food science & nutrition 13(6)
- Jianguo Zhu
- Yukun Sun
- Yao Dong
- Yunjiao Zhao
- Zhonghui Gai
- Shuguang Fang
- PubMed: 40548185
- DOI: 10.1002/fsn3.70490
- High evidence
Exploratory subgroup analysis revealed that in younger participants (<53 years age), LA85 supplementation significantly reduced the incidence of AAD (p=0.008) and effectively eliminated persistent diarrhea episodes.
- Effect
- Beneficial
- Effect size
- Large
- Significant
- Yes
- Dose
- 2×10^9 CFU/day