Best Supplements for Reduced Diarrhea Rate
Ranked by research evidence. Compare 34 supplements across 65 papers from the biomedical literature, with effect direction, evidence strength, and dose range for each.
Top picks by evidence
- High evidence11 studies
Across 11 studies, 8 reported beneficial effects of Lactobacillus reuteri DSM 17938 on reducing diarrhea rates, with effect sizes ranging from small to large (predominantly small to moderate). The most common dose was around 1-4 × 10^8 CFU/day, and the most studied population was children with acute gastroenteritis or diarrhea. Evidence shows a moderate-sized beneficial effect, particularly in clinical settings with hospitalized or outpatient children.
Dose: 1 × 10^8 to 4 × 10^8 CFU/dayProduct matchBioGaia — Kids, Immune Active with L. Reuteri + Vitamin D, Orange· $26.99 · ★4.8 (510) - Moderate evidence11 studies
Across 11 studies, 8 reported beneficial effects of Saccharomyces boulardii on reducing diarrhea rates, with effect sizes ranging from small to large (predominantly small to moderate). The most-studied populations are children with acute gastroenteritis or Helicobacter pylori infection, and a common dose was 250 mg once or twice daily. Median study duration was 33 days (across 2 studies that reported it), though durations varied widely.
Dose: 250 mg once daily to 500 mg twice daily - Moderate evidence4 studies
Across all 4 studies, Saccharomyces boulardii consistently showed beneficial effects on reducing diarrhea rate, with small to moderate effect sizes. The most robust evidence comes from two randomized controlled trials in children with acute diarrhea and adults with small intestinal bacterial overgrowth, reporting statistically significant reductions in diarrhea duration or resolution. The median study duration was 35 days (reported in 1 study), and doses ranged from not stated to 500 mg twice daily.
Dose: 500 mg twice daily
- HighLactobacillus reuteri DSM 17938Across 11 studies, 8 reported beneficial effects of Lactobacillus reuteri DSM 17938 on reducing diarrhea rates, with effect sizes ranging from small to large (predominantly small to moderate). The most common dose was around 1-4 × 10^8 CFU/day, and the most studied population was children with acute gastroenteritis or diarrhea. Evidence shows a moderate-sized beneficial effect, particularly in clinical settings with hospitalized or outpatient children. · Dose: 1 × 10^8 to 4 × 10^8 CFU/day8 beneficial3 neutral11 studies
- Moderatesaccharomyces boulardiiAcross 11 studies, 8 reported beneficial effects of Saccharomyces boulardii on reducing diarrhea rates, with effect sizes ranging from small to large (predominantly small to moderate). The most-studied populations are children with acute gastroenteritis or Helicobacter pylori infection, and a common dose was 250 mg once or twice daily. Median study duration was 33 days (across 2 studies that reported it), though durations varied widely. · Dose: 250 mg once daily to 500 mg twice daily8 beneficial3 neutral11 studies
- ModerateSaccharomyces boulardiiAcross all 4 studies, Saccharomyces boulardii consistently showed beneficial effects on reducing diarrhea rate, with small to moderate effect sizes. The most robust evidence comes from two randomized controlled trials in children with acute diarrhea and adults with small intestinal bacterial overgrowth, reporting statistically significant reductions in diarrhea duration or resolution. The median study duration was 35 days (reported in 1 study), and doses ranged from not stated to 500 mg twice daily. · Dose: 500 mg twice daily4 beneficial4 studies
- ModerateLactobacillus rhamnosus GGAcross 3 studies, all reported beneficial effects of Lactobacillus rhamnosus GG on reducing diarrhea rate. The predominant effect size was large, with two meta-analyses and one RCT showing significant reductions in antibiotic-associated diarrhea risk (from 22.4% to 12.3%) and rotavirus diarrhea recurrence (25% vs 46%). One meta-analysis reported a small but significant reduction in diarrhea duration (0.85 days). Evidence primarily comes from children, though one meta-analysis included adults.3 beneficial3 studies