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Evidence-Based Supplement Research
Evidence-Based Supplement Research

Best Supplements for Reduced Diarrhea Rate

Ranked by research evidence. Compare 26 supplements across 43 papers from the biomedical literature, with effect direction, evidence strength, and dose range for each.

Top picks by evidence

  • Moderate evidence8 studies

    Across 8 studies, 5 reported beneficial effects of Lactobacillus reuteri DSM 17938 on reducing diarrhea rate, predominantly with small to moderate effect sizes. The most consistent evidence comes from children with acute gastroenteritis, including a meta-analysis showing a reduction in diarrhea duration. However, 3 neutral findings indicate the effect is not universal, particularly in some acute gastroenteritis and prevention contexts.

    Dose: 1×10⁸ to 2×10⁹ CFU/day
  • Moderate evidence7 studies

    Across 7 studies, 5 reported beneficial effects of Saccharomyces boulardii on reducing diarrhea rates, with effect sizes ranging from moderate to large, while 2 studies found neutral results. The most commonly evaluated dose was 250 mg twice daily or 500 mg/day, and the strongest evidence comes from children with acute diarrhea and patients on antibiotic or radiotherapy regimens. Most studies were short-term (under 2 weeks), and no consistent form information was reported.

    Dose: 250 mg twice daily (500 mg/day) to 1000 mg/day
26 supplements
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