Best Supplements for Reduced Diarrhea Rate
Ranked by research evidence. Compare 29 supplements across 50 papers from the biomedical literature, with effect direction, evidence strength, and dose range for each.
Top picks by evidence
- High evidence8 studies
Across 8 studies, 6 reported beneficial effects of Saccharomyces boulardii for reducing diarrhea, with most showing moderate-to-large effect sizes. The evidence primarily comes from pediatric populations with acute diarrhea or Helicobacter pylori infection, using typical doses of 250-1000 mg/day. However, two neutral studies (one in radiotherapy patients and one in hospitalized adults) suggest the benefit may not be universal.
Dose: 250-1000 mg/day - Moderate evidence8 studies
Across 8 studies, 5 reported beneficial effects of Lactobacillus reuteri DSM 17938 on reducing diarrhea rate, predominantly with small to moderate effect sizes. The most consistent evidence comes from children with acute gastroenteritis, including a meta-analysis showing a reduction in diarrhea duration. However, 3 neutral findings indicate the effect is not universal, particularly in some acute gastroenteritis and prevention contexts.
Dose: 1×10⁸ to 2×10⁹ CFU/dayProduct matchBioGaia — Kids, Immune Active with L. Reuteri + Vitamin D, Orange· $26.99 · ★4.8 (510) - Low evidence3 studies
Across 3 studies, all reported beneficial small-to-moderate effects of Saccharomyces boulardii on reducing diarrhea rates, with 3 of 3 showing statistically significant findings. The most-studied population appears to be children with acute diarrhea and adults with SIBO, with doses ranging from 500 mg twice daily to unspecified amounts. Effects were predominantly small, and the median study duration was 35 days.
Dose: 500 mg twice daily
- Highsaccharomyces boulardiiAcross 8 studies, 6 reported beneficial effects of Saccharomyces boulardii for reducing diarrhea, with most showing moderate-to-large effect sizes. The evidence primarily comes from pediatric populations with acute diarrhea or Helicobacter pylori infection, using typical doses of 250-1000 mg/day. However, two neutral studies (one in radiotherapy patients and one in hospitalized adults) suggest the benefit may not be universal. · Dose: 250-1000 mg/day6 beneficial2 neutral8 studies
- ModerateLactobacillus reuteri DSM 17938Across 8 studies, 5 reported beneficial effects of Lactobacillus reuteri DSM 17938 on reducing diarrhea rate, predominantly with small to moderate effect sizes. The most consistent evidence comes from children with acute gastroenteritis, including a meta-analysis showing a reduction in diarrhea duration. However, 3 neutral findings indicate the effect is not universal, particularly in some acute gastroenteritis and prevention contexts. · Dose: 1×10⁸ to 2×10⁹ CFU/day5 beneficial3 neutral8 studies
- LowSaccharomyces boulardiiAcross 3 studies, all reported beneficial small-to-moderate effects of Saccharomyces boulardii on reducing diarrhea rates, with 3 of 3 showing statistically significant findings. The most-studied population appears to be children with acute diarrhea and adults with SIBO, with doses ranging from 500 mg twice daily to unspecified amounts. Effects were predominantly small, and the median study duration was 35 days. · Dose: 500 mg twice daily3 beneficial3 studies