New evidence
Combining vitamin C with thiamine (B1) failed to reduce mortality in sepsis — an umbrella review of 31 systematic reviews found no statistically significant effect.
This is the first broad synthesis to look specifically at vitamin C plus thiamine combinations in sepsis, and the null result means the routine use of this pairing is not supported by current evidence — but because this is an early umbrella review, the picture could shift with better-designed trials.
Researchers analyzed 31 systematic reviews on intravenous vitamin C for sepsis and found that combining it with thiamine (vitamin B1) did not reduce mortality, organ dysfunction, or the time patients needed vasopressors. The only possible benefit appeared in certain narrow conditions with vitamin C alone, but the evidence was low-to-moderate certainty — so for now, these combinations don't offer a survival advantage in sepsis.
Where this fits in the evidence
This is among the first studies we've indexed on Vitamin B1 for Reduced Mortality Risk — treat it as an early signal until more research accumulates.
The study
- Systematic Review
- 2026-07-01
- PloS one
This is a plain-language summary of a research finding, not medical advice. Pillser surfaces research signals to help you decide what's worth investigating — always consult a qualified professional before changing what you take.