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Evidence-Based Supplement Research
Evidence-Based Supplement Research
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Surprising

Vitamin C matched a steroid for post-surgery pain relief in 107 hip-replacement patients — but unlike dexamethasone, it didn't spike blood sugar.

This single randomized trial suggests vitamin C could be a useful option for managing postoperative pain without the metabolic side effects of steroids, but the result is from a small clinical population undergoing major surgery, so it doesn't tell us whether vitamin C works for everyday pain in healthy people.

In a randomized trial of 107 people recovering from total hip replacement, those given vitamin C reported significantly less pain on day one after surgery compared to a control group — and the effect was similar to the steroid dexamethasone. However, the vitamin C group avoided the blood glucose spikes the steroid caused, though nausea and vomiting still occurred. This is one of seven studies on vitamin C for pain, most of which found a benefit, but the doses used in these studies varied widely, so there's no single recommended amount yet.

Where this fits in the evidence

Pillser has synthesized 7 studies on Vitamin C for Reduced Pain — overall evidence strength: High.

Across 7 studies, 6 reported beneficial effects (predominantly small to moderate in size) on reducing pain. Evidence is strongest for post-surgical pain and clinical conditions such as carpal tunnel syndrome and oral health issues. Effects were observed at a median study duration of 60 days, with some studies showing benefit within days.

The study

Efficacy of Vitamin C as Glucocorticoid Substitute for Reducing Pain and Inflammation After Total Hip Arthroplasty: A Randomized Controlled Trial.

  • Randomized Controlled Trial (RCT)
  • n = 107
  • 2025-04-10
  • The Journal of bone and joint surgery. American volume
More on Vitamin CMore on Reduced Pain

This is a plain-language summary of a research finding, not medical advice. Pillser surfaces research signals to help you decide what's worth investigating — always consult a qualified professional before changing what you take.

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