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Vitamin K2 slowed stiffening of arteries by roughly 80% in a one-year trial — but only in post-menopausal women, and the placebo group's vessels stiffened alarmingly faster than expected.
This is a single, rigorous trial in a specific clinical population, so while the effect is large and statistically significant, it's premature to assume the same degree of benefit in younger people, men, or healthy adults.
In 165 post-menopausal women, those taking 180 µg of vitamin K2 (MK-7) daily for a year saw their arterial stiffness increase by only 9.4%, compared to a 49.1% increase in the placebo group — a roughly five-fold slowdown. The same supplement also significantly lowered blood pressure and improved the arteries' ability to expand. Because the study targeted women already past menopause, who are at higher risk for vascular aging, it's unclear whether similar results would appear in other groups.
Where this fits in the evidence
This is among the first studies we've indexed on Vitamin K2 for Reduced Vascular Stiffness — treat it as an early signal until more research accumulates.
The study
- Randomized Controlled Trial (RCT)
- n = 165
- 2025-02-27
- Nutrients
- PubMed: 40077685
- DOI: 10.3390/nu17050815
- Full study breakdown →
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