Best Supplements for Improved Flow-Mediated Dilation
Ranked by research evidence. Compare 18 supplements across 23 papers from the biomedical literature, with effect direction, evidence strength, and dose range for each.
Top picks by evidence
- Moderate evidence5 studies
Across 5 studies, all reported beneficial effects of L-citrulline on flow-mediated dilation (FMD), with effect sizes ranging from small to large (most commonly moderate). The median study duration was 28 days, and the most studied dose range was 6–10 g/day. Evidence primarily comes from clinical populations with hypertension, type 2 diabetes, or heart failure, suggesting L-citrulline may improve endothelial function in these groups.
Dose: 6–10 g/day
18 supplements
- ModerateL-CitrullineAcross 5 studies, all reported beneficial effects of L-citrulline on flow-mediated dilation (FMD), with effect sizes ranging from small to large (most commonly moderate). The median study duration was 28 days, and the most studied dose range was 6–10 g/day. Evidence primarily comes from clinical populations with hypertension, type 2 diabetes, or heart failure, suggesting L-citrulline may improve endothelial function in these groups. · Dose: 6–10 g/day5 beneficial5 studies