Best Supplements for Improved Flow-Mediated Dilation
Ranked by research evidence. Compare 20 supplements across 25 papers from the biomedical literature, with effect direction, evidence strength, and dose range for each.
Top picks by evidence
- Moderate evidence5 studies
Across all 5 studies, L-citrulline supplementation consistently improved flow-mediated dilation (FMD), with 5 of 5 studies reporting beneficial effects and all reaching statistical significance. Effect sizes were predominantly moderate, with one large effect observed. The most-studied doses were 6 g/day and 3 g/day, and effects were typically observed over 4–12 weeks in clinical populations such as individuals with high-normal blood pressure, hypertensive postmenopausal women, and patients with type 2 diabetes.
Dose: 3000–6000 mg/day
20 supplements
- ModerateL-CitrullineAcross all 5 studies, L-citrulline supplementation consistently improved flow-mediated dilation (FMD), with 5 of 5 studies reporting beneficial effects and all reaching statistical significance. Effect sizes were predominantly moderate, with one large effect observed. The most-studied doses were 6 g/day and 3 g/day, and effects were typically observed over 4–12 weeks in clinical populations such as individuals with high-normal blood pressure, hypertensive postmenopausal women, and patients with type 2 diabetes. · Dose: 3000–6000 mg/day5 beneficial5 studies