TCF7L2-rs7903146 polymorphism modulates the effect of artichoke leaf extract supplementation on insulin resistance in metabolic syndrome: a randomized, double-blind, placebo-controlled trial.
- 2018-09
- RCT · n = 80
- Journal of integrative medicine 16(5)
- Mehranghiz Ebrahimi-Mameghani
- Mohammad Asghari-Jafarabadi
- Khatereh Rezazadeh
- PubMed: 30177026
- DOI: 10.1016/j.joim.2018.05.006
- High evidence
- Clinical
ALE supplementation decreased insulin level and the homeostasis model assessment of insulin resistance (HOMA-IR) in patients with the TT genotype of TCF7L2-rs7903146 polymorphism (P < 0.05).
- Effect
- Beneficial
- Effect size
- Small
- Significant
- Yes
- Dose
- 1800 mg/d as four tablets