Ashwagandha and Reduced Depression Symptoms

Doses used in studies

mg/day: 600 (median 600, IQR 600–600) — 1 study

Time to effect

Median: 8 weeks · IQR 8 weeks–8 weeks · Range 8 weeks–8 weeks — Reported in 1 of 1 study

Safety in these studies

Overall tolerabilityReported
No significant difference between Withania somnifera and the comparators was found for safety and tolerability.
from: The effect of Withania somnifera (Ashwagandha) on mental health symptoms in individuals wi

1 of 1 paper

The effect of Withania somnifera (Ashwagandha) on mental health symptoms in individuals with mental disorders: systematic review and meta-analysis.

2025-10-27
Review
BJPsych open 11(6)
- Mattia Marchi
- Pietro Grenzi
- Antonio Travascio
- Daniele Uberti
- Edoardo De Micheli
- Fabio Quartaroli
- Giuseppe Laquatra
- Luca Pingani
- Silvia Ferrari
- Gian M Galeazzi

PubMed: 41140145
DOI: 10.1192/bjo.2025.10885

4 Insights on

Reduced Depression Symptoms

Low evidence
Clinical

depression (SMD: -1.28 (95% CI: -2.40; -0.16)) ... but not for depression ... The effect size was confirmed using the Bayesian for anxiety but not for depression

Effect: Neutral
Effect size: Large
Significant: No
Dose: 600 mg/day (median dose)