Black Cumin and Reduced Intercellular Adhesion Molecule-1

• Does Nigella sativa supplementation improve cardiovascular disease risk factors? A comprehensive GRADE-assessed systematic review and dose-response meta-analysis of 82 randomized controlled trials.

  • 2025-09
  • Meta-Analysis · n = 5,026
  • Pharmacological research 219
  • • Ali Jafari
    • Helia Mardani
    • Amir Hossein Faghfouri
    • Zahra Mirzaei Fashtali
    • Mohtaram Hashemi
    • Matin Abdollahi Yousefabady
    • Reihane Javid
    • Sahar Golabi
    • Bahareh Arghavan
    • Vali Musazadeh
    • Mahshid Naghashpour

  • PubMed: 40714301
  • DOI: 10.1016/j.phrs.2025.107882

  35 Insights on

  • Reduced Intercellular Adhesion Molecule-1

  • High evidence

  N. sativa supplementation significantly improved ... intercellular adhesion molecule-1 (ICAM-1)

  Effect

  Beneficial

  Effect size

  Small

  Significant

  Yes

  Dose

  200 to 4600 mg/day

• The effect of Nigella sativa oil on vascular dysfunction assessed by flow-mediated dilation and vascular-related biomarkers in subject with cardiovascular disease risk factors: A randomized controlled trial.

  • 2022-04-12
  • RCT
  • Phytotherapy research : PTR 36(5)
  • • Hadi Emamat
    • Seyyed Hossein Mousavi
    • Jalal Kargar Shouraki
    • Ebrahim Hazrati
    • Sayid Mahdi Mirghazanfari
    • Esmaeil Samizadeh
    • Maryam Hosseini
    • Vahid Hadi
    • Saeid Hadi

  • PubMed: 35412685
  • DOI: 10.1002/ptr.7441

  7 Insights on

  • Reduced Intercellular Adhesion Molecule-1

  • High evidence
  • Clinical

  there was no significant difference in ... ICAM-1 levels between groups

  Effect

  Neutral

  Effect size

  Small

  Significant

  No

  Dose

  two capsules of 500 mg N. sativa oil daily (1000 mg/day)