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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Black Cumin and Reduced Pain

Doses used in studies

mL/every 8 hours: 2.5 (median 2.5, IQR 2.5–2.5) — 1 study

Time to effect

Median: 4.3 weeks · IQR 4.3 weeks–4.3 weeks · Range 4.3 weeks–4.3 weeks — Reported in 1 of 2 studies

Safety in these studies

Overall tolerabilityReported
There was no side effect.
from: Efficacy and safety of oral Nigella sativa oil for symptomatic treatment of knee osteoarth

2 of 2 papers

A holistic guide to effective prevention and treatment for kidney stones: a systematic review exploring anti-urolithiasis approaches.
- 2025-10-20
- Systematic Review
- Naunyn-Schmiedeberg's archives of pharmacology 399(3)
- - Anood T Allam
  - Ahmed M El-Dessouki
  - Riham A El-Shiekh
  - Dina Abou-Hussein
  - Mahmoud Abdelmouti Mahmoud
  - Wagih H Marcus
  - Hassan A Ruby
- PubMed: 41116039
- DOI: 10.1007/s00210-025-04658-y
4 Insights on
- Reduced Pain
- High evidence
- Clinical
Nigella sativa performed as well as or better than tamsulosin in both pain relief and stone passage
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Efficacy and safety of oral Nigella sativa oil for symptomatic treatment of knee osteoarthritis: A double-blind, randomized, placebo-controlled clinical trial.
- 2022-11
- RCT · n = 58
- Complementary therapies in clinical practice 49
- - Hasan Fallah Huseini
  - Reza Mohtashami
  - Elaheh Sadeghzadeh
  - Soraya Shadmanfar
  - Fataneh Hashem-Dabaghian
  - Saeed Kianbakht
- PubMed: 36150238
- DOI: 10.1016/j.ctcp.2022.101666
10 Insights on
- Reduced Pain
- High evidence
- Clinical
The VAS scores were decreased by 33.96 ± 17.04% (NS oil group) and 9.21 ± 0.32% (placebo group) (p < 0.001)
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Dose
2.5 mL every 8 hours