Black Cumin and Reduced Pain Intensity

• The effect of Nigella Sativa emulgel on episiotomy wound healing and pain intensity in primiparous women: A triple-blind randomized controlled trial.

  • 2025-06-04
  • RCT
  • PloS one 20(6)
  • • Mahsa Maghalian
    • Afsaneh Alizadeh
    • Fatemeh Raphi
    • Ziba Islambulchilar
    • Laleh Khodaie
    • Mahsan Nabighadim
    • Simin Taghavi
    • Mojgan Mirghafourvand

  • PubMed: 40465634
  • DOI: 10.1371/journal.pone.0325112

  2 Insights on

  • Reduced Pain Intensity

  • High evidence
  • Clinical

  lower pain scores (VAS: MD -0.74, 95% CI -1.3 to -0.11; p = 0.021)

  Effect

  Beneficial

  Effect size

  Small

  Significant

  Yes

  Dose

  topical emulgel applied three times daily for 7 days

• Comparing the efficacy of a novel mucoadhesive patch containing Nigella sativa 10% with triamcinolone 0.1% in patients with erosive-atrophic oral lichen planus: A pilot study.

  • 2024-05-26
  • Clinical Trial · n = 10
  • Clinical and experimental dental research 10(3)
  • • Atessa Pakfetrat
    • Zahra Delavarian
    • Mahshid Malakooti
    • Hossein Bagheri
    • Habibollah Esmaily
    • Mahsa Ghorbani
    • Pooya Saeedi

  • PubMed: 38798063
  • DOI: 10.1002/cre2.886

  3 Insights on

  • Reduced Pain Intensity

  • Moderate evidence
  • Clinical

  Pain and burning intensity decreased in both groups throughout the sessions, with the N. sativa group showing a greater reduction than the triamcinolone group. The reduction in burning intensity within each group was significant (p < .001).

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

  Dose

  10% extract in mucoadhesive patch