Cocoa Consumption Decreases Oxidative Stress, Proinflammatory Mediators and Lipid Peroxidation in Healthy Subjects: A Randomized Placebo-Controlled Dose-Response Clinical Trial.
- 2023-03-28
- RCT
- High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension 30(3)
- Davide Grassi
- Francesca Mai
- Martina De Feo
- Remo Barnabei
- Augusto Carducci
- Giovambattista Desideri
- Stefano Necozione
- Leen Allegaert
- Herwig Bernaert
- Claudio Ferri
- PubMed: 36976481
- DOI: 10.1007/s40292-023-00571-8
- High evidence
cocoa reduced sICAM-1 mean values [from 1190.2 to 1123.0; 906.3; 741.7 and 625.6 pg/mL (p = 0.0198 and p = 0.0016, for 500 and 800 mg respectively]
- Effect
- Neutral
- Effect size
- Small
- Significant
- No
- Dose
- 200 mg/day