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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Griffonia and Reduced Pain Intensity

Doses used in studies

mg/day: 100 (median 100, IQR 100–100) — 1 study

Time to effect

Median: 4 weeks · IQR 4 weeks–4 weeks · Range 4 weeks–4 weeks — Reported in 1 of 1 study

Safety in these studies

mild, transient adverse eventsReported
Mild, transient adverse events occurred in two participants (11%) during Griffonia simplicifolia intake.
from: The Effect of Griffonia simplicifolia on Pain Intensity, Central and Peripheral Sensitizat

1 of 1 paper

The Effect of Griffonia simplicifolia on Pain Intensity, Central and Peripheral Sensitization, and Pain Modulation in Healthy Volunteers-A Randomized, Double-Blinded, Placebo-Controlled Crossover Trial.
- 2026-05-19
- RCT · n = 17
- Nutrients 18(10)
- - Anselm Johannes Schlemmer
  - Sascha Hammer
  - Simon Fandler-Höfler
  - Kordula Lang-Illievich
  - Helmar Bornemann-Cimenti
- PubMed: 42197069
- DOI: 10.3390/nu18101609
9 Insights on
- Reduced Pain Intensity
- High evidence
- Rigorous Journal
- Adults
Griffonia simplicifolia showed no significant effect on acute pain perception after RPHA (β = -4.17; 95% CI -14.44 to 6.10; p = 0.401).
Effect
Neutral
Effect size
Small
Significant
No
Dose
100 mg once daily for 28 days