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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Gymnema and Improved Insulin Sensitivity

Doses used in studies

mg/day: 600 (median 600, IQR 600–600) — 2 studies

Time to effect

Median: 2.8 months · IQR 2.8 months–2.8 months · Range 2.8 months–2.8 months — Reported in 1 of 2 studies

2 of 2 papers

Effect of Gymnema sylvestre Administration on Metabolic Syndrome, Insulin Sensitivity, and Insulin Secretion.
- 2017-08
- RCT · n = 600
- Journal of medicinal food 20(8)
- - Laura Y Zuñiga
  - Manuel González-Ortiz
  - Esperanza Martínez-Abundis
- PubMed: 28459647
- DOI: 10.1089/jmf.2017.0001
5 Insights on
- Improved Insulin Sensitivity
- High evidence
- Large Human Trial
- Clinical
without modifying the components of MetS, insulin secretion, and insulin sensitivity
Effect
Neutral
Effect size
Small
Significant
No
Dose
300 mg capsules twice daily before breakfast and dinner for a total of 600 mg per day for 12 weeks
Effect of Gymnema sylvestre Administration on Glycemic Control, Insulin Secretion, and Insulin Sensitivity in Patients with Impaired Glucose Tolerance.
- 2020-05-27
- RCT · n = 30
- Journal of medicinal food 24(1)
- - Luis A Gaytán Martínez
  - Luis A Sánchez-Ruiz
  - Laura Y Zuñiga
  - Manuel González-Ortiz
  - Esperanza Martínez-Abundis
- PubMed: 32460589
- DOI: 10.1089/jmf.2020.0024
7 Insights on
- Improved Insulin Sensitivity
- High evidence
- Clinical
with an increment in the Matsuda index (1.8 ± 0.8 vs. 2.4 ± 1.2, P = .008)
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Dose
300 mg b.i.d.