Research synthesisLow evidenceSmall effect3 studies · 3 beneficial · 0 neutral · 0 harmful
Across 3 studies, all reported beneficial effects of Gymnema sylvestre on reducing low-density lipoprotein (LDL) cholesterol, with effect sizes ranging from small to moderate. The most-studied dose was 300 mg twice daily (600 mg/day), and effects were typically observed at 12 weeks. Evidence is derived from clinical populations, including patients with metabolic syndrome and impaired glucose tolerance.
- Effective dose range: 300 mg twice daily (600 mg/day)
- Studied populations: patients with metabolic syndrome, patients with impaired glucose tolerance
Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Two of the three studies had small sample sizes (24 and 30 participants), and one study reported only a borderline significant effect for VLDL rather than LDL directly.
Generated Jul 13, 2026