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Evidence-Based Supplement Research
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Lemon Balm and Reduced Diastolic Blood Pressure

Research synthesisLow evidenceModerate effect3 studies · 2 beneficial · 1 neutral · 0 harmful

Across 3 studies, 2 reported beneficial effects of lemon balm on reducing diastolic blood pressure, with moderate to large effect sizes, while 1 meta-analysis found a neutral, non-significant effect. The two positive RCTs studied stage 1 hypertensive patients at doses of 10 mL/day (liquid extract) and 400 mg/day (powder), with effects observed after 28 days. The evidence is limited in volume and mixed in outcome, with beneficial effects seen in individual RCTs but not confirmed in the sole meta-analysis.

  • Effective dose range: 400 mg/day (powder) or 10 mL/day (liquid extract)
  • Studied populations: patients with stage 1 hypertension

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. The neutral finding from the meta-analysis (2020) contrasts with the two positive RCTs, which may reflect differences in study design, population, or dosage. With 2 of 3 studies beneficial (67%), available evidence is positive but not overwhelmingly so; the meta-analysis had a lower evidence score and included broader cardio-metabolic outcomes.

Generated Jul 11, 2026
Doses used in studies
  • mL/day: 10 (median 10, IQR 10–10) — 1 study
  • mg/day: 400 (median 400, IQR 400–400) — 1 study
Time to effect
Median: 4 weeks · IQR 4 weeks–4 weeks · Range 4 weeks–4 weeks — Reported in 2 of 3 studies
Safety in these studies
3 of 3 papers
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