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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Lemon Balm and Reduced Diastolic Blood Pressure

Doses used in studies

mL/day: 10 (median 10, IQR 10–10) — 1 study

Time to effect

Median: 4 weeks · IQR 4 weeks–4 weeks · Range 4 weeks–4 weeks — Reported in 1 of 2 studies

Safety in these studies

Overall tolerabilityReportedSerious adverse event
No serious adverse events were reported.
from: Effects of Melissa officinalis (Lemon Balm) on cardio-metabolic outcomes: A systematic rev

2 of 2 papersPopulation:

Comparison of the effects of Echium amoenum and Melissa officinalis on hypertension in stage 1 hypertensive patients: A randomized, triple-blind, three-arm clinical trial.
- 2025-12
- RCT · n = 105
- Complementary therapies in medicine 95
- - Melika Jafari Dehnayebi
  - Pouya Zeidy
  - Soheila Shamsikhani
  - Mehdi Salehi
  - Mehdi Safarabadi
- PubMed: 41101745
- DOI: 10.1016/j.ctim.2025.103266
2 Insights on
- Reduced Diastolic Blood Pressure
- High evidence
- Large Human Trial
- Clinical
The Melissa officinalis group had the greatest decrease in ... DBP (4 mmHg). Significant within-group reductions in both SBP and DBP were observed in the Melissa officinalis ... groups (p < 0.001).
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Dose
10 mL/day
Effects of Melissa officinalis (Lemon Balm) on cardio-metabolic outcomes: A systematic review and meta-analysis.
- 2020-07-02
- Meta-Analysis
- Phytotherapy research : PTR 34(12)
- - Javad Heshmati
  - Mojgan Morvaridzadeh
  - Mahdi Sepidarkish
  - Siavash Fazelian
  - Mehran Rahimlou
  - Amirhossein Omidi
  - Andriko Palmowski
  - Akbar Asadi
  - Farzad Shidfar
- PubMed: 32614129
- DOI: 10.1002/ptr.6744
9 Insights on
- Reduced Diastolic Blood Pressure
- High evidence
MO intake was not associated with statistically significant changes in … diastolic blood pressure
Effect
Neutral
Effect size
Small
Significant
No