Across all 4 studies, all reported beneficial effects on cognitive function, with effect sizes predominantly moderate. The most studied dose was 1.8 g per day, and effects were observed in both healthy adults and clinical populations. Median study duration was 56 days, suggesting that benefits can be seen within 4-12 weeks of supplementation.
Caveats: Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). The evidence base includes only 4 studies, with one being a low-quality narrative review; sample sizes were frequently unreported. Most trials lacked a specified dose, and one study examined only acute effects (60 minutes post-dose), limiting generalizability to chronic use.
Although commonly unreported, potential side effects of HE include stomach discomfort, headache, and allergic reactions.
from: Benefits, side effects, and uses of Hericium erinaceus as a supplement: a systematic revieAlthough commonly unreported, potential side effects of HE include stomach discomfort, headache, and allergic reactions.
from: Benefits, side effects, and uses of Hericium erinaceus as a supplement: a systematic revieAlthough commonly unreported, potential side effects of HE include stomach discomfort, headache, and allergic reactions.
from: Benefits, side effects, and uses of Hericium erinaceus as a supplement: a systematic revieparticipants performed quicker on the Stroop task (p = 0.005) at 60 min post dose.
MMSE alone showed that oral intake of H. erinaceus significantly improved cognitive functions and prevented from the deterioration.
Mini-Mental State Examination scores from one RCT and one PCT showed a combined weighted mean increase of 1.17 in the intervention group.
The use of HE demonstrated positive significant differences in results obtained from behavioural, histological and biochemical assessments from both human clinical trials and animal model studies accentuating its utility for the improvement of cognitive function.