Across 4 studies, all reported beneficial effects on cognitive function, with moderate effect sizes observed in 3 studies and a small effect in 1 study. The median study duration was 56 days, suggesting effects may emerge after several weeks. The most specified dose was 1.8 g/day in one acute/chronic RCT, but dosing was not consistently reported.
Caveats: Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Evidence base is small (only 4 studies) — conclusions should be considered preliminary. One study is a narrative review with low evidence quality, and dosing was not consistently reported across studies.
Although commonly unreported, potential side effects of HE include stomach discomfort, headache, and allergic reactions.
from: Benefits, side effects, and uses of Hericium erinaceus as a supplement: a systematic revieAlthough commonly unreported, potential side effects of HE include stomach discomfort, headache, and allergic reactions.
from: Benefits, side effects, and uses of Hericium erinaceus as a supplement: a systematic revieAlthough commonly unreported, potential side effects of HE include stomach discomfort, headache, and allergic reactions.
from: Benefits, side effects, and uses of Hericium erinaceus as a supplement: a systematic revieparticipants performed quicker on the Stroop task (p = 0.005) at 60 min post dose.
MMSE alone showed that oral intake of H. erinaceus significantly improved cognitive functions and prevented from the deterioration.
Mini-Mental State Examination scores from one RCT and one PCT showed a combined weighted mean increase of 1.17 in the intervention group.
The use of HE demonstrated positive significant differences in results obtained from behavioural, histological and biochemical assessments from both human clinical trials and animal model studies accentuating its utility for the improvement of cognitive function.