Across 3 studies, all reported beneficial effects of Lion's Mane on cognitive function, with effect sizes ranging from small to moderate (predominantly moderate). The most robust evidence comes from a randomized controlled trial showing quicker Stroop task performance at 1.8 g/day over 28 days in healthy adults. The evidence base is small (only 3 studies), so conclusions should be considered preliminary.
Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). One study included participants with and without dementia, but findings may not generalize broadly.
Although commonly unreported, potential side effects of HE include stomach discomfort, headache, and allergic reactions.
from: Benefits, side effects, and uses of Hericium erinaceus as a supplement: a systematic revieAlthough commonly unreported, potential side effects of HE include stomach discomfort, headache, and allergic reactions.
from: Benefits, side effects, and uses of Hericium erinaceus as a supplement: a systematic revieAlthough commonly unreported, potential side effects of HE include stomach discomfort, headache, and allergic reactions.
from: Benefits, side effects, and uses of Hericium erinaceus as a supplement: a systematic revieparticipants performed quicker on the Stroop task (p = 0.005) at 60 min post dose.
Mini-Mental State Examination scores from one RCT and one PCT showed a combined weighted mean increase of 1.17 in the intervention group.
The use of HE demonstrated positive significant differences in results obtained from behavioural, histological and biochemical assessments from both human clinical trials and animal model studies accentuating its utility for the improvement of cognitive function.