Skip to main content

Evidence-Based Supplement Research

Evidence-Based Supplement Research

Perilla and Improved Cognitive Function

Doses used in studies

g/day: 0.88 (median 0.88, IQR 0.88–0.88) — 1 study

Time to effect

Median: 9.1 months · IQR 7.5 months–10.6 months · Range 6 months–12.2 months — Reported in 2 of 2 studies

Safety in these studies

Overall tolerabilityReported
Perilla seed oil had no adverse effect to kidney, liver, blood components or glucose metabolism.
from: Outcomes of Perilla Seed Oil as an Additional Neuroprotective Therapy in Patients with Mil

2 of 2 papersPopulation:

Outcomes of Perilla Seed Oil as an Additional Neuroprotective Therapy in Patients with Mild to Moderate Dementia: A Randomized Control Trial.
- 2019-02-04
- RCT · n = 182
- Current Alzheimer research 16(2)
- - Chuntida Kamalashiran
  - Kusuma Sriyakul
  - Junya Pattaraarchachai
  - Sombat Muengtaweepongsa
- PubMed: 30543172
- DOI: 10.2174/1567205016666181212153720
3 Insights on
- Improved Cognitive Function
- High evidence
- Large Human Trial
- Clinical
Cognitive function is not significantly different compared between groups.
Effect
Neutral
Effect size
Small
Significant
No
Perilla seed oil in combination with nobiletin-rich ponkan powder enhances cognitive function in healthy elderly Japanese individuals: a possible supplement for brain health in the elderly.
- 2022-03-07
- RCT
- Food & function 13(5)
- - Michio Hashimoto
  - Kentaro Matsuzaki
  - Koji Maruyama
  - Shahdat Hossain
  - Eri Sumiyoshi
  - Harumi Wakatsuki
  - Setsushi Kato
  - Miho Ohno
  - Yoko Tanabe
  - Yoko Kuroda
  - Shuhei Yamaguchi
  - Koji Kajima
  - Yasushi Ohizumi
  - Osamu Shido
- PubMed: 35171190
- DOI: 10.1039/d1fo03508h
1 Insight on
- Improved Cognitive Function
- High evidence
- Rigorous Journal
- Elderly
the POPP group showed significantly higher cognitive index scores than the PO group
Effect
Neutral
Effect size
Small
Significant
No
Dose
1.47 mL (0.88 g of ALA) daily