Outcomes of Perilla Seed Oil as an Additional Neuroprotective Therapy in Patients with Mild to Moderate Dementia: A Randomized Control Trial.

2019-02-04
Current Alzheimer research 16(2)
- Chuntida Kamalashiran
- Kusuma Sriyakul
- Junya Pattaraarchachai
- Sombat Muengtaweepongsa

PubMed: 30543172
DOI: 10.2174/1567205016666181212153720

Study Design

Type: Randomized Controlled Trial (RCT)
Sample size: n = 182
Population: 182 patients, with 94 in the experimental group and 88 in the placebo group, were able to complete the study
Methods: A double-blind, randomized-control trial (perilla seed oil versus placebo) in patients with mild to moderate dementia was conducted. Perilla seed oil or placebo was added on with standard treatment for six months.
Blinding: Double-blind
Duration: six months

Large Human Trial

Background

Dementia is a common medical disorder in the elderly. Oxidative stress plays a major role in the process of cognitive decline in dementia. Perilla seed oil demonstrates its neuroprotective effects via anti-oxidative mechanisms against dementia. We investigate neuroprotective effects of perilla seed oil as an additional treatment in patients with mild to moderate dementia.

Method

A double-blind, randomized-control trial (perilla seed oil versus placebo) in patients with mild to moderate dementia was conducted. Perilla seed oil or placebo was added on with standard treatment for six months. Cognitive function was compared at nine months after enrollment.

Result

182 patients, with 94 in the experimental group and 88 in the placebo group, were able to complete the study. Cognitive function is not significantly different compared between groups. However, the total cholesterol and LDL cholesterol were significantly lower in the experimental group. Perilla seed oil had no adverse effect to kidney, liver, blood components or glucose metabolism.

Conclusion

Perilla seed oil as additional neuroprotective therapy in patients with mild to moderate dementia does not improve cognitive function. Perilla seed oil significantly reduced total cholesterol and LDL cholesterol. A clinical trial is needed to prove the benefit of cholesterol-lowering effects with perilla seed oil in human.

Research Insights

Perilla→Improved Cognitive Function
Cognitive function is not significantly different compared between groups.
Effect
Neutral
Effect size
Small
Perilla→Reduced Blood Cholesterol
the total cholesterol and LDL cholesterol were significantly lower in the experimental group.
Effect
Beneficial
Effect size
Small
Perilla→Reduced LDL Cholesterol
the total cholesterol and LDL cholesterol were significantly lower in the experimental group.
Effect
Beneficial
Effect size
Small

Adverse Events Reported

Perilla→Overall tolerability
Perilla seed oil had no adverse effect to kidney, liver, blood components or glucose metabolism.
Finding
Reported