Pine and Augmented Endothelium-Dependent Vasodilation

• Pycnogenol, French maritime pine bark extract, augments endothelium-dependent vasodilation in humans.

  • 2007
  • RCT · n = 8
  • Hypertension research : official journal of the Japanese Society of Hypertension 30(9)
  • • Kenji Nishioka
    • Takayuki Hidaka
    • Shuji Nakamura
    • Takashi Umemura
    • Daisuke Jitsuiki
    • Junko Soga
    • Chikara Goto
    • Kazuaki Chayama
    • Masao Yoshizumi
    • Yukihito Higashi

  • PubMed: 18037769
  • DOI: 10.1291/hypres.30.775

  2 Insights on

  • Augmented Endothelium-Dependent Vasodilation

  • High evidence
  • Adults

  Pycnogenol, but not placebo, augmented FBF response to ACh, from 13.1 +/- 7.0 to 18.5 +/- 4.0 mL/min per 100 mL tissue (p<0.05).

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

  Dose

  180 mg/day