Pine and Reduced Forearm Blood Flow Response to Acetylcholine

Doses used in studies

mg/day: 180 (median 180, IQR 180–180) — 1 study

Time to effect

Median: 2 weeks · IQR 2 weeks–2 weeks · Range 2 weeks–2 weeks — Reported in 1 of 1 study

1 of 1 paper

Pycnogenol, French maritime pine bark extract, augments endothelium-dependent vasodilation in humans.

2007
RCT · n = 8
Hypertension research : official journal of the Japanese Society of Hypertension 30(9)
- Kenji Nishioka
- Takayuki Hidaka
- Shuji Nakamura
- Takashi Umemura
- Daisuke Jitsuiki
- Junko Soga
- Chikara Goto
- Kazuaki Chayama
- Masao Yoshizumi
- Yukihito Higashi

PubMed: 18037769
DOI: 10.1291/hypres.30.775

2 Insights on

Reduced Forearm Blood Flow Response to Acetylcholine

High evidence
Adults

The administration of N(G)-monomethyl-L-arginine, an NO synthase inhibitor, completely abolished Pycnogenol-induced augmentation of the FBF response to ACh.

Effect: Neutral
Effect size: Small
Significant: No
Dose: 180 mg/day