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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Pueraria Mirifica and Improved Vaginal Maturation Index

Doses used in studies

g/day: 0.5 (median 0.5, IQR 0.5–0.5) — 1 study
mg/day: 20–50 (median 35, IQR 20–50) — 1 study

Time to effect

Median: 4.2 months · IQR 3.5 months–4.9 months · Range 2.8 months–5.6 months — Reported in 2 of 2 studies

Safety in these studies

Overall tolerabilityNo significant difference
There was no significant difference of adverse effects between the Pueraria mirifica and placebo groups in this study.
from: Effect of Pueraria mirifica on vaginal health.

2 of 2 papersPopulation:

Effect of Pueraria mirifica on vaginal health.
- 2007-09
- RCT · n = 71
- Menopause (New York, N.Y.) 14(5)
- - Jittima Manonai
  - Apichart Chittacharoen
  - Urusa Theppisai
  - Hathai Theppisai
- PubMed: 17415017
- DOI: 10.1097/gme.0b013e3180399486
2 Insights on
- Improved Vaginal Maturation Index
- High evidence
- Adults
Pueraria mirifica increased vaginal maturation index (parabasal:intermediate:superficial cells) from 46:43:11 to 11:65:24 after 24 weeks of treatment.
Effect
Beneficial
Effect size
Large
Significant
Yes
Dose
20, 30, or 50 mg/day
Comparison of Pueraria mirifica gel and conjugated equine estrogen cream effects on vaginal health in postmenopausal women.
- 2017-02
- RCT
- Menopause (New York, N.Y.) 24(2)
- - Narathorn Suwanvesh
  - Jittima Manonai
  - Areepan Sophonsritsuk
  - Wichai Cherdshewasart
- PubMed: 27749740
- DOI: 10.1097/gme.0000000000000742
4 Insights on
- Improved Vaginal Maturation Index
- High evidence
- Clinical
The vaginal maturation index increased significantly in both treatment groups at week 12, from 22.44±22.28 to 47.56±29.00 and from 27.07±26.12 to 66.90±22.42 in the PM and the CEE groups, respectively (P<0.05).
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Dose
0.5 g of gel intravaginally daily for 2 weeks, then three times per week for 10 weeks