Senolytics dasatinib and quercetin in idiopathic pulmonary fibrosis: results of a phase I, single-blind, single-center, randomized, placebo-controlled pilot trial on feasibility and tolerability.
- 2023-02-28
- RCT
- EBioMedicine 90
- Anoop Nambiar
- Dean Kellogg
- Jaime Justice
- Martin Goros
- Jonathan Gelfond
- Rodolfo Pascual
- Shahrukh Hashmi
- Michal Masternak
- Larissa Prata
- Nathan LeBrasseur
- Andrew Limper
- Stephen Kritchevsky
- Nicolas Musi
- Tamara Tchkonia
- James Kirkland
- PubMed: 36857968
- DOI: 10.1016/j.ebiom.2023.104481
- High evidence
- Highly Cited
- Clinical
Frailty, pulmonary, or physical function were explored before and after intermittent D+Q; though under-powered to evaluate change, these measures do not appear to differ meaningfully between groups.
- Effect
- Neutral
- Effect size
- Small
- Significant
- No
- Dose
- 1250 mg/d