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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Quercetin and Reduced Tumor Necrosis Factor Alpha

Doses used in studies

mg/day: 500 (median 500, IQR 500–500) — 1 study

Time to effect

Median: 3 months · IQR 3 months–3 months · Range 3 months–3 months — Reported in 1 of 2 studies

2 of 2 papersPopulation:

Quercetins efficacy on bone and inflammatory markers, body composition, and physical function in postmenopausal women.
- 2025-03-07
- RCT
- Journal of bone and mineral metabolism 43(3)
- - Alyssa R Bailly
  - Garrett M Hester
  - Michaela G Alesi
  - Robert J Buresh
  - Yuri Feito
  - Christine M Mermier
  - Jeremy B Ducharme
  - Trisha A VanDusseldorp
- PubMed: 40053115
- DOI: 10.1007/s00774-025-01592-0
9 Insights on
- Reduced Tumor Necrosis Factor Alpha
- High evidence
- Adults
decreased IL-6 (p = 0.045; d = 0.73) and TNF-α (p = 0.021; d = 0.90) levels
Effect
Beneficial
Effect size
Large
Significant
Yes
Dose
500 mg once daily
Efficacy of dietary polyphenol supplement in patients with non-alcoholic fatty liver disease: a network meta-analysis.
- 2025-05-09
- Review · n = 132
- Frontiers in nutrition 12
- - Xiao-Cui Wang
  - Li Song
  - Xin-Han Wang
- PubMed: 40416369
- DOI: 10.3389/fnut.2025.1582861
7 Insights on
- Reduced Tumor Necrosis Factor Alpha
- High evidence
- Clinical
quercetin decreased serum TNF-α (99.47%)
Effect
Beneficial
Effect size
Small
Significant
Yes