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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Red Grape and Reduced Ferritin Level

Doses used in studies

mg/day: 100 (median 100, IQR 100–100) — 1 study

Time to effect

Median: 4 weeks · IQR 4 weeks–4 weeks · Range 4 weeks–4 weeks — Reported in 1 of 2 studies

Safety in these studies

Overall tolerabilityReported
The study aimed to investigate the iron-chelating, antioxidant, anti-inflammatory, and hepatoprotective activities of grape seed extract (GSE) supplement as well as its safety in β-thalassemia major (β-TM) pediatric patients receiving deferasirox as a standard iron-chelation therapy.
from: Grape seed extract in combination with deferasirox ameliorates iron overload, oxidative st

2 of 2 papers

Grape seed extract in combination with deferasirox ameliorates iron overload, oxidative stress, inflammation, and liver dysfunction in beta thalassemia children.
- 2023-11
- RCT · n = 30
- Complementary therapies in clinical practice 53
- - Sayeh Mottaghi
  - Hassan Abbaszadeh
- PubMed: 37832335
- DOI: 10.1016/j.ctcp.2023.101804
11 Insights on
- Reduced Ferritin Level
- High evidence
- Clinical
GSE supplement significantly attenuated the serum levels of ... ferritin (p = 0.017)
Effect
Beneficial
Effect size
Small
Significant
Yes
Dose
100 mg/day
Synergic Treatment of Plant-Based Antioxidants with Iron Chelators for Iron Overload in Transfusion-Dependent-Thalassemia Patients: A Systematic Review.
- 2025-07-01
- Review
- International journal of hematology-oncology and stem cell research 19(3)
- - Moe Thida Kyaw
  - Phyu Synn Oo
  - Afshan Sumera
  - Anupa Sivakumar
  - Carolina Santiago
  - Yin Nwe Aung
- PubMed: 41281788
- DOI: 10.18502/ijhoscr.v19i3.19289
5 Insights on
- Reduced Ferritin Level
- Low evidence
- Clinical
In contrast, quercetin and curcumin supplementation did not show a statistically significant difference compared to control groups in these outcomes.
Effect
Neutral
Effect size
Small
Significant
No