Resveratrol and Improved Clinical Attachment

• Resveratrol as an Adjunct Therapy in Periodontal Disease: A Systematic Review and Meta-Analysis.

  • 2026-07-07
  • Meta-Analysis
  • Nutrients 18(13)
  • • Suzanne Ying-Shan Su
    • I-Shiang Tzeng
    • Ting-Hsin Huang
    • Earl Fu

  • PubMed: 42451212
  • DOI: 10.3390/nu18132212

  4 Insights on

  • Improved Clinical Attachment

  • High evidence
  • Rigorous Journal
  • Clinical

  adjunctive resveratrol was associated with improvements in probing pocket depth and clinical attachment level compared with root planing alone in patients with periodontitis, as well as reductions in bleeding and plaque indices

  Effect

  Beneficial

  Effect size

  Small

  Significant

  Yes

• Impact of systemic resveratrol on non-surgical periodontal treatment of smokers: A 12-month randomized clinical trial.

  • 2025-08-30
  • RCT · n = 19
  • Clinical oral investigations 29(9)
  • • Vanessa Haguihara Lucchesi
    • Ana Paula Oliveira Giorgetti
    • Mônica Grazieli Corrêa
    • Vanessa G A Pecorari
    • Bruno Braga Benatti
    • Howard C Tenenbaum
    • Fabiano Ribeiro Cirano
    • Suzana Peres Pimentel
    • Márcio Zafallon Casati

  • PubMed: 40884630
  • DOI: 10.1007/s00784-025-06517-9

  6 Insights on

  • Improved Clinical Attachment

  • High evidence
  • Clinical

  RSV appeared to induce lower ... CAL [4.02 (0.90) - 3 months; 4.04 (0.81) - 6 months; 3.87 (0.78) - 12 months] ... as compared to Placebo [CAL: 4.43 (0.99) - 3 months; 4.24 ((0.89) - 6 months; 4.39 (0.93) - 12 months] throughout the time (p < 0.05).

  Effect

  Beneficial

  Effect size

  Small

  Significant

  Yes

  Dose

  500 mg/day