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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Resveratrol and Increased Antioxidant Enzyme Levels

Doses used in studies

mg/day: 400–800 (median 600, IQR 500–700) — 2 studies

Time to effect

Median: 10.3 weeks · IQR 9.4 weeks–11.1 weeks · Range 8.6 weeks–2.8 months — Reported in 2 of 2 studies

2 of 2 papers

Does Resveratrol Impact Oxidative Stress Markers in Patients with Head and Neck Cancer Receiving Home Enteral Nutrition?
- 2025-01-30
- RCT
- Nutrients 17(3)
- - Michał Ławiński
  - Katarzyna Zadka
  - Natalia Ksepka
  - Maima Matin
  - Kamil Wysocki
  - Dominika Karkocha
  - Aleksandra Gradowska
  - Atanas G Atanasov
  - Maciej Słodkowski
  - Agnieszka Wierzbicka
  - Artur Jóźwik
- PubMed: 39940362
- DOI: 10.3390/nu17030504
3 Insights on
- Increased Antioxidant Enzyme Levels
- High evidence
- Rigorous Journal
- Clinical
Significant increases in TAC and SOD activity were observed in both groups.
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Dose
400 mg of liposomal RES daily
Beneficial Role of Resveratrol on Oxidative Stress in Women with Polycystic Ovary Syndrome: A Randomized Controlled Trial.
- 2025-08-28
- RCT
- Reproductive sciences (Thousand Oaks, Calif.) 32(10)
- - Negar Ajabi Ardehjani
  - Marzieh Agha-Hosseini
  - Maryam Shabani Nashtaei
  - Mahshad Khodarahmian
  - Shadi Sadat Seyyed Ebrahimi
  - Mohammad Hossein Bagheri
  - Farzane Fereidouni
  - Tayebeh Rastegar
  - Fardin Amidi
- PubMed: 40877487
- DOI: 10.1007/s43032-025-01967-8
9 Insights on
- Increased Antioxidant Enzyme Levels
- High evidence
- Clinical
Although resveratrol increased Mn-SOD expression (P = 0.0914), its effects were not statistically significant.
Effect
Neutral
Effect size
Small
Significant
No
Dose
800 mg/day