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Evidence-Based Supplement Research
Evidence-Based Supplement Research
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Resveratrol and Increased Antioxidant Enzyme Levels

Research synthesisLow evidenceModerate effect3 studies · 2 beneficial · 1 neutral · 0 harmful

Across 3 studies, 2 reported beneficial moderate-sized effects of resveratrol on antioxidant enzyme levels, while 1 study found neutral effects. Effects were typically observed at 60–84 days, with a median study duration of 72 days. The limited evidence suggests potential benefits in clinical populations such as patients with type 2 diabetes and head and neck cancer, though the evidence base is small.

  • Effective dose range: 400–800 mg/day
  • Studied populations: patients with type 2 diabetes mellitus, patients with head and neck cancer receiving home enteral nutrition

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. One study in polycystic ovary syndrome found a neutral result, suggesting response may vary by population. Doses and forms varied, and one study used a liposomal form, which may influence bioavailability.

Generated Jul 10, 2026
Doses used in studies
  • mg/day: 400–800 (median 600, IQR 500–700) — 2 studies
Time to effect
Median: 10.3 weeks · IQR 9.4 weeks–11.1 weeks · Range 8.6 weeks–2.8 months — Reported in 2 of 3 studies
3 of 3 papers
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