Resveratrol and Increased Antioxidant Enzyme Levels

Research synthesisLow evidenceModerate effect3 studies · 2 beneficial · 1 neutral · 0 harmful

Across 3 studies, 2 reported beneficial moderate-sized effects of resveratrol on antioxidant enzyme levels, while 1 study found a neutral effect. Evidence is strongest in clinical populations (type 2 diabetes, head and neck cancer), with effects typically observed at 8-12 weeks (median study duration 72 days). The most-studied dose was 400-800 mg/day.

Effective dose range: 400-800 mg/day
Studied populations: patients with type 2 diabetes mellitus, patients with head and neck cancer receiving home enteral nutrition

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. One study in PCOS patients showed a non-significant trend toward increased Mn-SOD expression, suggesting the effect may not generalize to all populations. The meta-analysis (highest evidence score) reported low level of evidence for the glutathione peroxidase finding.

Generated Jun 10, 2026

Doses used in studies

mg/day: 400–800 (median 600, IQR 500–700) — 2 studies

Time to effect

Median: 10.3 weeks · IQR 9.4 weeks–11.1 weeks · Range 8.6 weeks–2.8 months — Reported in 2 of 3 studies

3 of 3 papers

The efficacy of resveratrol supplementation on inflammation and oxidative stress in type-2 diabetes mellitus patients: randomized double-blind placebo meta-analysis.
- 2025-01-13
- Meta-Analysis · n = 533
- Frontiers in endocrinology 15
- - Peiye Zhu
  - Yunrui Jin
  - Jiya Sun
  - Xia Zhou
- PubMed: 39872318
- DOI: 10.3389/fendo.2024.1463027
11 Insights on
- Increased Antioxidant Enzyme Levels
- High evidence
- Clinical
Supplementation with resveratrol significantly increased glutathione peroxidase levels (SMD = 0.38, 95%CI(0.03, 0.74), P = 0.04; Level of evidence:low)
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Dose
not specified in abstract
Does Resveratrol Impact Oxidative Stress Markers in Patients with Head and Neck Cancer Receiving Home Enteral Nutrition?
- 2025-01-30
- RCT
- Nutrients 17(3)
- - Michał Ławiński
  - Katarzyna Zadka
  - Natalia Ksepka
  - Maima Matin
  - Kamil Wysocki
  - Dominika Karkocha
  - Aleksandra Gradowska
  - Atanas G Atanasov
  - Maciej Słodkowski
  - Agnieszka Wierzbicka
  - Artur Jóźwik
- PubMed: 39940362
- DOI: 10.3390/nu17030504
3 Insights on
- Increased Antioxidant Enzyme Levels
- High evidence
- Rigorous Journal
- Clinical
Significant increases in TAC and SOD activity were observed in both groups.
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Dose
400 mg of liposomal RES daily
Beneficial Role of Resveratrol on Oxidative Stress in Women with Polycystic Ovary Syndrome: A Randomized Controlled Trial.
- 2025-08-28
- RCT
- Reproductive sciences (Thousand Oaks, Calif.) 32(10)
- - Negar Ajabi Ardehjani
  - Marzieh Agha-Hosseini
  - Maryam Shabani Nashtaei
  - Mahshad Khodarahmian
  - Shadi Sadat Seyyed Ebrahimi
  - Mohammad Hossein Bagheri
  - Farzane Fereidouni
  - Tayebeh Rastegar
  - Fardin Amidi
- PubMed: 40877487
- DOI: 10.1007/s43032-025-01967-8
9 Insights on
- Increased Antioxidant Enzyme Levels
- High evidence
- Clinical
Although resveratrol increased Mn-SOD expression (P = 0.0914), its effects were not statistically significant.
Effect
Neutral
Effect size
Small
Significant
No
Dose
800 mg/day

Resveratrol and Increased Antioxidant Enzyme Levels

The efficacy of resveratrol supplementation on inflammation and oxidative stress in type-2 diabetes mellitus patients: randomized double-blind placebo meta-analysis.

Does Resveratrol Impact Oxidative Stress Markers in Patients with Head and Neck Cancer Receiving Home Enteral Nutrition?

Beneficial Role of Resveratrol on Oxidative Stress in Women with Polycystic Ovary Syndrome: A Randomized Controlled Trial.