Resveratrol and Reduced Low-Density Lipoprotein Level

Research synthesisLow evidenceMixed effect size3 studies · 2 beneficial · 1 neutral · 0 harmful

Across 3 studies, 2 reported beneficial effects on LDL reduction (moderate effect in adults with MASLD, small effect in adults with T2DM), while one meta-analysis found no significant effect on LDL. Evidence is preliminary and mixed. The beneficial effects were observed in clinical populations with metabolic conditions, but doses were not consistently reported.

Studied populations: adults with metabolic dysfunction-associated steatotic liver disease (MASLD) or type 2 diabetes (T2DM)

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Results are mixed: a meta-analysis of 7 RCTs found no significant effect on LDL, while two systematic reviews reported significant reductions in LDL in specific populations (MASLD and T2DM). The neutral meta-analysis included a general hyperlipidemic population, suggesting the benefit may be population-specific.

Generated Jul 15, 2026

Safety in these studies

Overall tolerabilityReported
The included studies showed substantial heterogeneity in reported outcomes, which primarily focused on hepatic health, body weight, adverse events, glycemic control, blood lipids, and body composition.
from: Evaluating Bioactive-Substance-Based Interventions for Adults with MASLD: Results from a S

3 of 3 papersPopulation:

Evaluating Bioactive-Substance-Based Interventions for Adults with MASLD: Results from a Systematic Scoping Review.
- 2025-01-26
- Systematic Review · n = 4,572
- Nutrients 17(3)
- - Deepa Handu
  - Kim Stote
  - Tami Piemonte
- PubMed: 39940310
- DOI: 10.3390/nu17030453
6 Insights on
- Reduced Low-Density Lipoprotein Level
- High evidence
- Rigorous Journal
- Clinical
The included studies showed substantial heterogeneity in reported outcomes, which primarily focused on hepatic health, body weight, adverse events, glycemic control, blood lipids, and body composition.
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Anti-inflammatory mechanism of resveratrol's Triglyceride-lowering effect in hyperlipidemia: a meta-analysis integrated network pharmacology and molecular dynamics simulation.
- 2025-07-24
- Meta-Analysis · n = 337
- Clinical and experimental medicine 25(1)
- - Yinyan Shao
  - Junwei Shi
- PubMed: 40705097
- DOI: 10.1007/s10238-025-01809-6
3 Insights on
- Reduced Low-Density Lipoprotein Level
- High evidence
Meta-analysis of seven RCTs (n = 337) revealed that RES significantly reduced triglycerides (TG) but showed no significant effects on total cholesterol, low-density lipoprotein, or high-density lipoprotein.
Effect
Neutral
Effect size
Small
Significant
No
Dose
doses ranged across the included RCTs (not explicitly stated in abstract)
Clinical Efficacy of Curcumin, Resveratrol, Silymarin, and Berberine on Cardio-Metabolic Risk Factors Among Patients With Type 2 Diabetes Mellitus: A Systemic Review and Bayesian Network Meta-Analysis.
- 2025-05-29
- Systematic Review · n = 337
- Phytotherapy research : PTR 39(12)
- - Runyu Miao
  - Boxun Zhang
  - Danni Zhou
  - Mengjiao Kang
  - Jiaxing Tian
  - Linhua Zhao
  - Xiaolin Tong
- PubMed: 40439602
- DOI: 10.1002/ptr.8431
12 Insights on
- Reduced Low-Density Lipoprotein Level
- High evidence
- Clinical
Resveratrol significantly improved … low-density lipoprotein (LDL) … (P < 0.05)
Effect
Beneficial
Effect size
Small
Significant
Yes

Resveratrol and Reduced Low-Density Lipoprotein Level

Evaluating Bioactive-Substance-Based Interventions for Adults with MASLD: Results from a Systematic Scoping Review.

Anti-inflammatory mechanism of resveratrol's Triglyceride-lowering effect in hyperlipidemia: a meta-analysis integrated network pharmacology and molecular dynamics simulation.

Clinical Efficacy of Curcumin, Resveratrol, Silymarin, and Berberine on Cardio-Metabolic Risk Factors Among Patients With Type 2 Diabetes Mellitus: A Systemic Review and Bayesian Network Meta-Analysis.